而Curcuphenol，它是烹饪香料的常见成分，在海洋无脊椎动物和植物中自然存在，在逆转免疫逃避、通过恢复侵袭性癌症抗原表达机制 (APM)，从而使转移性肿瘤重新获得免疫识别方面，已被鉴定为新的候选药物。通过明确的设计合成了两种Curcuphenol类似物，这两种类似物在转移性前列腺癌和肺癌细胞中一致诱导了APM的表达。随后发现这两种类似物具有一种先前未描述过的组蛋白脱乙酰酶 (HDAC) 增强活性。值得注意的是，Curcuphenol处理的细胞的H3K27ac ChIPseq分析显示，诱导的表观基因组标记与干扰素-γ观察到的全基因组模式变化相似，干扰素-γ是调控先天和适应免疫的细胞因子。这些观察结果将膳食成分与修饰基因表达的表观遗传程序相联系，从而调节处于准备就绪状态的免疫。版权所有 © 2023 Ellis, Dada, Nohara, Saranchova, Munro, Pfeifer, Eyford, Morova, Williams, Cheng, Lack, Andersen和Jefferies。

Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of the antigen presentation machinery (APM) in invasive cancers, thereby resurrecting the immune recognition of metastatic tumours. Two synthetic curcuphenol analogues, were prepared by informed design that demonstrated consistent induction of APM expression in metastatic prostate and lung carcinoma cells. Both analogues were subsequently found to possess a previously undescribed histone deacetylase (HDAC)-enhancing activity. Remarkably, the H3K27ac ChIPseq analysis of curcuphenol-treated cells reveals that the induced epigenomic marks closely resemble the changes in genome-wide pattern observed with interferon-γ, a cytokine instrumental for orchestrating innate and adaptive immunity. These observations link dietary components to modifying epigenetic programs that modulate gene expression guiding poised immunity.Copyright © 2023 Ellis, Dada, Nohara, Saranchova, Munro, Pfeifer, Eyford, Morova, Williams, Cheng, Lack, Andersen and Jefferies.