抑郁症与非酒精性脂肪性肝病（NAFLD）存在关联。有关抑郁症对NAFLD相关死亡的影响的数据正在完善中。我们旨在研究抑郁症与NAFLD在美国的全因/特定因素死亡率的关联。 我们对跨2007-2016年的美国国家健康与营养调查数据中的11,877名NAFLD个体进行了分析，这些个体与2019年的死亡数据有关联。NAFLD的定义是在无已知慢性肝病原因情况下，利用肝脏脂肪变性指数进行诊断。我们使用患者健康问卷评估了抑郁症和由抑郁症引起的功能障碍。 在中位随访时间为7.6年的期间，与无抑郁症的NAFLD个体相比，有抑郁症的NAFLD个体的全因死亡风险增加了35%（危险比[HR]：1.35，95%可信区间[CI]：1.03-1.75），在对人口统计学、生活方式和临床风险因素进行调整后。具有由抑郁症引起的功能障碍的NAFLD个体的全因死亡风险增加了62%（HR：1.62，95% CI：1.10-2.39）。NAFLD患者中的抑郁症与心血管死亡风险增加约50%相关，而具有功能障碍的个体与未具有功能障碍的个体相比，心血管死亡风险增加了2倍（HR：2.07，95% CI：1.30-3.30）。然而，在有无抑郁症的NAFLD中，癌症和意外死亡率之间没有显著差异。 在美国，抑郁症与NAFLD个体的全因和心血管死亡风险增加相关。 © 2023 Stichting European Society for Clinical Investigation Journal Foundation. 由John Wiley & Sons Ltd.出版。

Depression has been associated with nonalcoholic fatty liver disease (NAFLD). Data addressing the impact of depression on NAFLD-related mortality are evolving. We aim to study the association of depression in NAFLD and all-cause/cause-specific mortality in the United States.A total of 11,877 individuals with NAFLD in the 2007-2016 National Health and Nutrition Examination Survey with the availability of linked mortality through 2019 were analysed. NAFLD was defined by utilizing the hepatic steatosis index in the absence of known causes of chronic liver disease. Depression and functional impairment due to depression were assessed using the Patient Health Questionnaire.During the median follow-up of 7.6 years, individuals with depression among individuals with NAFLD had a 35% higher all-cause mortality than those without depression (hazard ratio [HR]: 1.35, 95% confidence interval [CI]: 1.03-1.75) after adjusting for demographic, lifestyle and clinical risk factors. NAFLD with functional impairment due to depression had a 62% higher all-cause mortality than NAFLD without functional impairment (HR: 1.62, 95% CI: 1.10-2.39). Depression in NAFLD was associated with an approximately 50% increase in the risk for cardiovascular mortality, with a 2-fold higher cardiovascular mortality in those with functional impairment compared to those without (HR: 2.07, 95% CI: 1.30-3.30). However, there was no significant difference in cancer- and accident-related mortalities in NAFLD with or without depression.Depression among individuals with NAFLD was associated with a higher risk for all-cause and cardiovascular mortality in the United States.© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.