在牛类中，原发性肺肿瘤很少见。对于这一物种中这些肿瘤的病理学发现的研究是有限的。本研究旨在描述牛状原发性和转移性肺癌的组织学和免疫组织化学结果。我们对涉及肺部的19例上皮肿瘤进行了回顾性研究。组织学上，大多数肿瘤被分类为原发性肺肿瘤，包括不同腺癌亚型（4/19, 21%）和腺鳞癌（3/19, 16%），其次是鳞状细胞癌（6/19, 32%），转移性子宫腺癌（4/19, 21%），转移性肝细胞癌（1/19, 5%）和转移性胆管癌（1/19, 5%）。通过免疫组织化学，所有肿瘤对泛细胞角蛋白呈阳性反应，并有4/19（21%）对波形蛋白呈阳性反应。原发性肺肿瘤对甲状腺转录因子-1具有免疫反应性（6/7），而只有其中2例对napsin A呈阳性反应。所有有鳞状分化的病例（9/9）对细胞角蛋白（CK）5/6呈阳性反应，而其中只有7例对p40呈阳性反应。CK20、CK7和CK8/18在原发性和转移性肺癌中显示不同的免疫反应性，但对于确认粘液性腺癌和转移性胆管癌的诊断非常重要。HepPar-1只在转移性肝细胞癌中呈阳性。本研究中转移性子宫腺癌的病例数量有限，限制了对该肿瘤特定免疫表型的确定。免疫组织化学证明是确认这些肿瘤正确分类的重要工具。

Primary pulmonary neoplasms in cattle are rare. There are few studies on the pathological findings of these neoplasms in this species. This study aimed to describe the histological and immunohistochemical findings of primary and metastatic pulmonary carcinomas in cattle. We conducted a retrospective study of 19 cases of epithelial neoplasms with pulmonary involvement. Histologically, most of the neoplasms were classified as primary pulmonary neoplasms, including different adenocarcinoma subtypes (4/19, 21%) and adenosquamous carcinomas (3/19, 16%), followed by squamous cell carcinoma (6/19, 32%), metastatic uterine adenocarcinoma (4/19, 21%), metastatic hepatocellular carcinoma (1/19, 5%), and metastatic cholangiocarcinoma (1/19, 5%). By immunohistochemistry, all neoplasms were positive for pancytokeratin, and 4/19 (21%) were positive for vimentin. Primary pulmonary neoplasms had immunoreactivity for thyroid transcription factor-1 (6/7), while only 2 of these cases were positive for napsin A. All cases with squamous differentiation (9/9) had immunoreactivity for cytokeratin (CK) 5/6, while only 7 of these cases were positive for p40. CK20, CK7, and CK8/18 showed varied immunoreactivity in the primary and metastatic pulmonary carcinomas but were important markers to confirm the diagnosis of primary mucinous adenocarcinoma and metastatic cholangiocarcinoma. HepPar-1 was only positive in the metastatic hepatocellular carcinoma. The limited number of cases of metastatic uterine adenocarcinomas in this study precluded identification of a specific immunophenotype for this tumor. Immunohistochemistry proved to be an important tool to confirm the proper classification of these neoplasms.