脓疱性坏疽（PG）是一种罕见的炎症性皮肤病，其特点是与自身免疫性疾病相关的皮肤溃疡。虽然已经报道了用糖皮质激素和肿瘤坏死因子抑制剂进行免疫抑制治疗PG的有效性，但对于严重溃疡病变的PG患者是否使用负压闭合引流（NPWT）仍存在争议。在本文中，我们报道了一位76岁患有类风湿性关节炎的女性患者，在行足前部畸形手术后发展为PG的病例。在接受阿巴塞普和全身系统糖皮质激素治疗时，患者通过NPWT显示了对于深部溃疡病变的改善。随后采用局部糖皮质激素治疗导致PG缓解。该病例表明，在免疫抑制条件下使用NPWT，不会加重病理反应，并可能有助于治疗严重溃疡性PG。 ©2023年日本风湿病学会。由牛津大学出版社发表。版权所有。若需要权限，请发送电子邮件至：journals.permissions@oup.com。

Pyoderma gangrenosum (PG) is a rare inflammatory skin disease characterized by skin ulcers that are associated with autoimmune diseases. Although the effectiveness of immunosuppression with glucocorticoids and tumor necrosis factor inhibitors in treating PG has been reported, the utility of negative-pressure wound therapy (NPWT) for severe ulcerative lesions in patients with PG remains controversial. Herein, we report the case of a 76-year-old woman with rheumatoid arthritis who developed PG after undergoing surgery for a forefoot deformity. The patient showed improvement in deep ulcer lesions through NPWT while receiving treatment with abatacept and systemic glucocorticoids. Subsequent topical glucocorticoid therapy led to the remission of the PG. This case suggests that NPWT, when used under immunosuppressive conditions, does not exacerbate the pathergy and may be beneficial for treating severe ulcerative PG.© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.