研究动态
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儿童前体B细胞淋巴母细胞性淋巴瘤的诊断病理工作中的18F-FDG-PET/CT成像。

18 F-FDG-PET/CT imaging in diagnostic workup of pediatric precursor B-cell lymphoblastic lymphoma.

发表日期:2023 Aug 28
作者: Emma Kroeze, Laura Arias Padilla, Birgit Burkhardt, Andishe Attarbaschi, Hannah von Mersi, Rejin Kebudi, Rutger A J Nievelstein, Nelleke Tolboom, Melanie M Hagleitner, Roland P Kuiper, Auke Beishuizen, Jan L C Loeffen
来源: Bone & Joint Journal

摘要:

目前,18 F-氟脱氧葡萄糖正电子发射计算机断层扫描(PET/CT)显像在B-细胞前体淋巴母细胞性淋巴瘤(BCP-LBL)的标准诊断中没有使用,并且目前尚不清楚PET/CT显像是否会导致与黄金标准显像方法在病变检测方面的一致性。因此,我们进行了一项回顾性队列研究,纳入32名小儿BCP-LBL患者,并通过审查当地显像报告确定病变定位。在59%的患者中,协议性显像和PET/CT之间存在不一致,主要包括PET/CT检测到的额外病变,通常在淋巴结和骨骼中或PET/CT中骨髓未受累。如果PET/CT在确定疾病确切分期方面具有主导作用,这将导致31%的患者疾病分期不同,并分别导致28%的患者选择不同的治疗分支。© 2023 Wiley Periodicals LLC。
18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) imaging is currently not used in standard diagnostics for B-cell precursor lymphoblastic lymphoma (BCP-LBL), and it is unknown whether PET/CT imaging would lead to agreement between detection of lesions with the gold standard imaging methods. Therefore, we performed a retrospective cohort study in which we included 32 pediatric BCP-LBL patients and determined localizations by reviewing local imaging reports. There was a disagreement between protocol-based imaging and PET/CT in 59% of the patients, and the discrepancies mostly comprise of additional lesions detected with PET/CT, typically in lymph node and bone or the absence of bone marrow involvement with PET/CT. If PET/CT was leading in determining definite stage of disease, this would lead to a different stage and therapy branch in 31% and 28% of the patients, respectively.© 2023 Wiley Periodicals LLC.