随着针对乳腺癌的精确药物治疗及局部区域治疗的降低，乳腺外科医生的角色在不断演变。乳腺外科肿瘤专家应带头制定预防策略，并帮助提高高风险女性对风险降低药物（RRMEDS）的接受程度。帮助女性了解她们患乳腺癌的风险将有助于启动风险降低药物的使用。RRMEDS引起的副作用担忧仍然是接受程度的重要障碍。低剂量的他莫昔芬已经证明可以帮助缓解副作用并减少接受治疗的女性的流失率，应作为外科医生在RRMEDS中的一部分来考虑。©2023. Society of Surgical Oncology.

The role of the breast surgeon continues to evolve in an era of improved precision pharmacological agents combating breast cancer and de-escalation of locoregional treatments. Surgical breast oncologists should lead the effort to create preventive strategies and help to improve the uptake of risk-reducing medications (RRMEDS) for women at higher risk of developing breast cancer. Helping women to understand their risk of developing breast cancer will help the initiation of RRMEDS. Fear of side effects caused by these RRMEDS remains a significant obstacle for uptake. Low-dose tamoxifen has shown to help mitigate side effects and reduce attrition rate of women who initiated therapy and should be considered as part of the surgeon's armamentarium for RRMEDS.© 2023. Society of Surgical Oncology.