乳腺癌是一种需要多模式治疗的疾病，手术切除肿瘤是治愈性治疗的一个重要组成部分。肥胖，定义为体质指数（BMI）> 30，已与手术并发症的增加相关。此外，肌肉减退，一种逐渐丧失肌肉量的病状，已与乳腺癌治疗结果更差相关联。肌肉减退随年龄增加、不活动和不良饮食而发生，导致患者虚弱，可能增加医疗治疗的并发症。即使是BMI较高的患者也可能会出现肌肉减退（称为肌肉减退性肥胖）。我们调查了肌肉减退与乳腺癌手术并发症的关联。 我们对接受骨骼肌质量生物电阻抗谱分析并在我院接受手术的乳腺癌患者进行了回顾性研究。患者特征、治疗数据、手术类型和并发症信息从病历中获取。多变量逻辑回归模型用于将肌肉减退和BMI与手术并发症关联起来，纠正其他患者特征。 我们分析了682例Ⅰ至Ⅲ期乳腺癌患者。在多变量逻辑回归中，控制年龄、BMI、合并症和手术类型（切除部分乳房、乳房切除伴或不伴重建），肌肉减退（p = 0.66）与手术并发症无关。肥胖在接受重建乳房切除的患者中与较高的手术并发症率相关（p = 0.01）。在我们的研究中，更复杂的手术方法与更高的手术并发症风险相关。 与接受部分乳房切除或乳房切除不重建的患者相比，接受乳房切除重建的患者更有可能出现术后并发症，而肥胖与后者组中并发症风险更高相关。我们没有发现肌肉减退与不良手术结果率之间的相关性。 © 2023. 作者（们），在Springer Science+Business Media, LLC的专有许可下，Springer Nature的一部分。

Breast cancer is a disease that requires multimodality treatment, and surgical resection of the tumor is a critical component of curative intent treatment. Obesity, defined as a body mass index (BMI) > 30, has been associated with increased surgical complications. Additionally, sarcopenia, a condition of gradual loss of muscle mass, has been associated with worse breast cancer treatment outcomes. Sarcopenia occurs with increased age, inactivity, and poor diet leading to patient frailty, which can increase medical treatment complications. Even patients with high BMI can have sarcopenia (termed sarcopenic obesity). We investigated the association of sarcopenia with surgical complications for breast cancer.A retrospective review was performed of patients diagnosed with breast cancer who received bioelectrical impedance spectrometry analysis of skeletal muscle mass and had surgery at our institution. Patient characteristics, treatment data, surgical type and complications were obtained from medical records. Multivariate logistic regression models were used to associate sarcopenia status and BMI with surgical complications, adjusted for other patient characteristics.We analyzed 682 patients with stage I to III breast cancer. On multivariable logistic regression controlling for age, BMI, comorbidities, and types of surgeries (lumpectomy, mastectomy with or without reconstruction), sarcopenia (p = 0.66) was not associated with surgical complications. Obesity was associated with a higher rate of surgical complications in patients who received mastectomy with reconstruction (p = 0.01). More complex surgical approaches were associated with a higher risk of surgical complications in our series.Compared with those undergoing lumpectomy or mastectomy without reconstruction, patients undergoing mastectomy with reconstruction were more likely to experience postoperative complications and obesity was associated with higher risk of complication in the latter group. We did not identify a correlation between sarcopenia and rate of adverse surgical outcomes.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.