有机氯农药(OC P)因其与类固醇信号通路的相互作用而被提议为潜在的乳腺癌致癌物。然而，流行病学结果并不一致。大多数研究都将乳腺癌(BC)视为一个单一实体，而未考虑不同的分子表达情况，包括雌激素受体(ER)、孕激素受体(PR)和HER2，这些表达情况可能会与这些污染物的相关性不同。因此，我们根据系统综述和荟萃分析评估了OCP的生物浓度与BC之间的关联，根据其分子受体表达情况分类。在141篇符合完整文本审查条件的文章中，有9篇符合纳入标准。分子表达的报告方式是不同的；因此，荟萃分析只能包括8篇文章。研究发现β-六六六和反非六基氯对ER +肿瘤有负面关联，六氯苯和ER-肿瘤有关联。p,p'-二氯二苯二氯乙烯、顺非六基氯和敌敌畏与BC没有关联，由于缺乏数据，无法评估OCP与HER2表达或三阴性肿瘤之间的关联。结果表明，某些OCP可能与BC的ER表达有关。然而，由于数据稀缺，证据并不确凿。我们确定了填补知识空白和增加研究可比性的几个方法学方面。©2023年。作者(s)独家许可给施普林格自然瑞士控股公司。

Organochlorine pesticides (OCP) have been proposed as potential mammary carcinogens since they interact with steroid signaling pathways. However, the epidemiological results are not conclusive. Most studies have evaluated breast cancer (BC) as a single entity without considering the different molecular expressions, including estrogen receptor (ER), progesterone receptor (PR), and HER2, that could differ in their association with these contaminants. Hence, we assessed the association between biological concentration of OCP and BC, according to its molecular receptor expression, based on a systematic review and meta-analysis.Of the 141 articles eligible for full-text review, nine met the inclusion criteria. The way in which molecular expression was reported was heterogeneous; therefore, the inclusion of studies in the meta-analysis was limited to eight articles. A negative association was identified for β-hexachlorocyclohexane and trans-nonachlor with ER + tumors and between hexachlorobenzene and ER - tumors. No associations were observed for p,p'-dichlorodiphenyldichloroethylene, cis-nonachlor, and dieldrin, and it was not possible to evaluate the associations between OCP with HER2 expression or triple-negative tumors due to lack of data. The results suggest that some OCP might be associated with BC depending on the expression of ER. However, the evidence is not conclusive due to the scarce data. We identified several methodological aspects to fill the gaps in knowledge and increase the comparability among studies.© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.