为解决儿童癌症患者的照料者所面临的负面心理状况，心理教育干预（PEIs）已作为辅助治疗手段使用。本系统回顾和荟萃分析的目的在于评估PEIs对儿童癌症患者的照料者在减少焦虑和抑郁症状、提高健康相关生命质量（HRQoL）和应对技巧方面的效果。为了发现与儿童癌症患者的照料者相关的PEIs研究，对十个英文数据库进行了搜索。研究纳入标准如下：（1）参与者为接受治疗的儿童癌症患者的照料者；（2）评估焦虑、抑郁症状、HRQoL和应对结果的心理教育干预；和（3）对照组采用常规护理、等候名单或主动对照。对数据进行了荟萃分析和叙事综述。 共有十四个随机对照试验被纳入。PEIs对焦虑水平（SMD：-0.59，95% CI [-0.92，-0.25]，p = 0.0007）、生活质量（SMD：-0.31，95% CI [-0.00，-0.61]，p = 0.05）和抑郁症状（SMD：-1.18，95% CI [-2.08，-0.28]，p = 0.01）在介入后立即表现出积极效果。PEIs效果在长期随访中对抑郁症状（SMD：-0.52，95% CI [-1.54，-0.36]，p = 0.0004）保持稳定。类似地，综合数据显示PEIs在改善应对技巧方面具有有效性。 该回顾提供证据表明PEIs能够有效减少照料者在儿童癌症患者中的负面心理状况并改善应对技巧。然而，由于方法学缺陷和评估干预措施的异质性，需要进一步研究以确定最有效的PEIs设计并提高证据的质量。 版权©2023作者。由约翰威立出版社出版的《心理肿瘤学》。

Psychoeducation interventions (PEIs) have been used as an adjunct treatment for negative psychological outcomes in caregivers of children with cancer. This systematic review and meta-analysis aimed to evaluate the evidence on the effectiveness of PEIs in reducing anxiety and depressive symptoms and improving health-related quality of life (HRQoL) and coping skills in caregivers of children with cancer.Ten English databases were searched to identify studies on PEIs for caregivers of children with cancer. Studies inclusion criteria were as follows: (1) participants who were caregivers of children with cancer receiving treatment; (2) psychoeducational interventions assessing anxiety, depressive symptoms, HRQoL, and coping outcomes; and (3) usual care, waitlist, or active control as a control group. Meta-analysis and narrative synthesis were used to analyse data.Fourteen randomised control trials were included. PEIs have a beneficial effect on anxiety levels (SMD: -0.59, 95% CI [-0.92, -0.25], p = 0.0007), quality of life (SMD: -0.31, 95% CI [-0.00, -0.61], p = 0.05) and depressive symptoms (SMD: -1.18, 95% CI [-2.08, -0.28], p = 0.01) immediately post-intervention. The effect of PEIs was maintained at long-term follow-up on depressive symptoms (SMD: -0.52, 95% CI [-1.54, -0.36], p = 0.0004). Similarly, the synthesised data suggest that PEIs are effective in improving coping skills.The review provides evidence that PEIs effectively reduce negative psychological outcomes and improve coping skills in caregivers of children with cancer. However, due to methodological flaws and heterogeneity of the interventions evaluated, more research is needed to determine the most effective PEI design and improve the quality of evidence.© 2023 The Authors. Psycho-Oncology published by John Wiley & Sons Ltd.