研究类型2糖尿病持续时间和癌症发生率之间的关联。在临床实践研究数据链数据库中，我们识别了130,764名年龄≥35岁在诊断时患有类型2糖尿病的个体，并将其与医院和死亡记录进行了关联。我们使用性别分层的Royston-Parmar模型，并使用两个时间尺度来估计1998年1月1日至2019年1月14日期间各年龄段和糖尿病持续时间的全部癌症、英国最常见的四种癌症（结直肠癌、肺癌、前列腺癌、乳腺癌）以及与肥胖相关的癌症（如肝癌、卵巢癌）的发生率。在1,089,923人年的随访期内，共发生了18,977例新发癌症。在相同年龄下，男性和女性的所有癌症发病率在持续时间从诊断到20年之间没有变化；相反，对于任何持续时间来说，年龄与癌症发病率之间存在着强有力的正相关关系。在男性中，60岁时20年与5年的持续时间比率（95%置信区间）为1.18（0.82-1.69），而80岁时为0.90（0.75-1.08）；在女性中，相应的比率为1.07（0.71-1.63）和0.84（0.66-1.05）。这种模式也适用于四种最常见的癌症。对于与肥胖相关的癌症而言，虽然BMI较高的个体通常患癌风险更高，但在任何BMI水平上与持续时间之间均没有相关性。在本研究中，我们没有发现类型2糖尿病持续时间和患癌风险之间的关联证据，较长持续时间与衰老有关的较高风险。© 2023年美国糖尿病协会。

To investigate the association between duration of type 2 diabetes and cancer incidence.In the Clinical Practice Research Datalink database, we identified 130,764 individuals with type 2 diabetes aged ≥35 years at diagnosis who were linked to hospital and mortality records. We used sex-stratified Royston-Parmar models with two time scales to estimate incidence rates of all cancers, the four commonest cancers in the United Kingdom (colorectal, lung, prostate, breast), and the obesity-related cancers (e.g., liver, ovary) between 1 January 1998 and 14 January 2019, by age and diabetes duration.During 1,089,923 person-years, 18,977 incident cancers occurred. At the same age, rates of all cancers in men and women did not vary across durations ranging from diagnosis to 20 years; conversely, for any duration, there was a strong, positive association between age and cancer rates. In men, the rate ratio (95% CI) comparing 20 with 5 years of duration was 1.18 (0.82-1.69) at 60 years of age and 0.90 (0.75-1.08) at 80 years; corresponding ratios in women were 1.07 (0.71-1.63) and 0.84 (0.66-1.05). This pattern was observed also for the four commonest cancers. For obesity-related cancers, although rates were generally higher in individuals with a higher BMI, there was no association with duration at any level of BMI.In this study, we did not find evidence of an association between duration of type 2 diabetes and risk of cancer, with the higher risk observed for longer durations related to ageing.© 2023 by the American Diabetes Association.