微小RNA (miRNA) 是一类广泛研究的非编码RNA，其特点是长度短（18-25核苷酸）。miRNA的精确功能尚未完全阐明，然而，越来越多的研究表明它们参与多种生理过程，并在病理条件下发生失调。其中，miRNA-185 (miR-185) 是在人类疾病中广泛研究的一种miRNA，已发现在代谢紊乱、哮喘、虚弱、精神分裂症和肝炎等疾病中发挥功用。值得注意的是，许多癌症研究报告了miR-185在细胞系、肿瘤组织和患者血浆样本中的下调表达，而且其在体外和体内均显示对癌细胞的恶性特性具有抑制作用。因此，在人类恶性肿瘤中，miR-185可以被认为是一个抑癌miRNA，然而也有少数研究报告了不一致的结果。miR-185被建议作为一种预后/诊断生物标志物，还被发现具有临床潜力，特别是用于癌症患者的早期诊断和预后预测。在本综述中，我们概述了有关miR-185在不同人类疾病中的功能和临床意义的研究，重点关注癌症。Copyright © 2023 Elsevier GmbH. 保留所有权利。

MicroRNAs (miRNAs) are a widely-studied class of non-coding RNAs characterized by their short length (18-25 nucleotides). The precise functions of miRNAs are not well-elucidated; however, an increasing number of studies suggest their involvement in various physiologic processes and deregulation in pathologic conditions. miRNA-185 (miR-185) is among the mostly-studied miRNAs in human diseases, which is found to play putative roles in conditions like metabolic disorders, asthma, frailty, schizophrenia, and hepatitis. Notably, many cancer studies report the downregulation of miR-185 in cell lines, tumor tissues, and plasma specimens of patients, while it demonstrates a suppressing role on the malignant properties of cancer cells in vitro and in vivo. Accordingly, miR-185 can be considered a tumor suppressor miRNA in human malignancies, while a few studies also report inconsistent findings. Being suggested as a prognostic/diagnostic biomarker, mi-185 is also found to offer clinical potentials, particularly for early diagnosis and prediction of the prognosis of cancer patients. In this review, we have outlined the studies that have evaluated the functions and clinical significance of miR-185 in different human diseases with a particular focus on cancer.Copyright © 2023 Elsevier GmbH. All rights reserved.