不同类型的癌症已被证明miR-195的表达水平下调，其起到抗肿瘤作用。miR-195家族成员通过靶向不同的促肿瘤基因mRNA的3'-UTR，可以抑制肿瘤细胞增殖、血管生成、上皮间质转化和转移、免疫抑制、糖酵解、药物耐药性以及肿瘤干细胞的发展。miR-195已被确定为一种肿瘤抑制性miRNA，在多种癌症中，尤其是妇科恶性肿瘤如宫颈癌、子宫内膜癌和卵巢癌中发挥着重要作用。因此，恢复miR-195的表达应被视为妇科癌症的预防或治疗的潜在治疗方法。本综述将介绍miR-195在妇科恶性肿瘤中介导的最新抗肿瘤效应的数据，重点介绍其下游信号通路和靶基因，以及前瞻性的治疗技术。版权所有 © 2023 Elsevier GmbH。保留所有权利。

Different cancer types have been shown to have down-regulated expression levels of miR-195 as an anti-tumor agent. MiR-195 family members can inhibit cancer cell proliferation, angiogenesis, epithelial-mesenchymal transition and metastases, immunosuppression, glycolysis, drug resistance, and cancer stem cell development by targeting the 3'-UTR of the mRNA of different pro-tumor genes. MiR-195 identified as a tumor suppressor miR in a variety of cancers, most notably gynecological malignancies such as cervical, endometrial, and ovarian carcinoma. As a result, restoring miR-195 expression should be regarded as a potential therapy for either prevention or treatment of gynecological cancers. This review will present the most recent data about miR-195-mediated anti-tumor effects in gynecological malignancies, emphasizing its downstream signaling pathways and target genes, as well as prospective treatment techniques.Copyright © 2023 Elsevier GmbH. All rights reserved.