口腔乳头状增生性鳞状丘疹病（OVH）指的是口腔黏膜上呈白色或粉红色的突起斑块或肿块，表面可以呈现鳞状或乳头状。鉴于其潜在的恶性转化可能性，追求积极治疗并对酒窝进行密切监测至关重要。在这里，我们报告了一例43岁男性患者左颊黏膜上出现大面积OVH的病例，该病例采用激光消融联合5-氨乙基酮丙酸（ALA）介导的光动力疗法（ALA-PDT）成功治疗。经过两次治疗后，病变完全消退，并在18个月的随访中没有发现复发。因此，激光消融联合ALA-PDT可能是一种治疗大面积OVH的有效且安全的方法。版权所有©2023 Elsevier B.V. 发布。

Oral verrucous hyperplasia (OVH) refers to a whitish or pink elevated plaque or mass on the oral mucosa with either verrucous or papillary surface. Given its potential of malignant transformation, it is crucial to pursue aggressive treatment and close surveillance to the lesion. Herein, we present a case of a 43-year-old male patient with large area OVH on the left buccal mucosa who was successfully treated using diode laser ablation combined with 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT). After two sessions of treatment, the lesions regressed completely, and no recurrence was observed at the 18-month follow-up. Therefore, diode laser ablation combined with ALA-PDT may be an efficient and safe treatment modality for large area OVH.Copyright © 2023. Published by Elsevier B.V.