长链非编码（lnc）RNA曾一度被认为是垃圾和无用的，但现在广泛认识到它们在细胞中具有重要功能。lncRNA定义为非编码RNA，长度大于200个核苷酸，调控基因表达的所有步骤。它们具有多样的起源，可从内含子、基因间区域或重叠区域中产生，以正义或反义方向。lncRNA主要在转录水平上发挥作用，而在翻译水平上的作用较少被提及。然而，该领域的参考文献越来越多。本综述关于调控翻译的lncRNA揭示了广泛的基因表达调控领域，至少涉及九种不同的分子机制。此外，所有这些lncRNA都参与不同的病理过程，包括癌症、心血管疾病和神经退行性疾病。版权所有 © 2023. Elsevier B.V.出版。

Long non-coding (lnc) RNAs, once considered as junk and useless, are now broadly recognized to have major functions in the cell. LncRNAs are defined as non-coding RNAs of more than 200 nucleotides, regulate all steps of gene expression. Their origin is diverse, they can arise from intronic, intergenic or overlapping region, in sense or antisense direction. LncRNAs are mainly described for their action on transcription, while their action at the translational level is more rarely cited. However, the bibliography in the field is more and more abundant. The present synopsis of lncRNAs involved in the control of translation reveals a wide field of regulation of gene expression, with at least nine distinct molecular mechanisms. Furthermore, it appears that all these lncRNAs are involved in various pathologies including cancer, cardiovascular and neurodegenerative diseases.Copyright © 2023. Published by Elsevier B.V.