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大血管血管炎患者及非大血管血管炎患者的CT扫描中血管钙化的患病率和分布:一项配对横断面研究。

Prevalence and distribution of vascular calcifications at CT scan in patients with and without large vessel vasculitis: a matched cross-sectional study.

发表日期:2023 Aug
作者: Giulia Besutti, Chiara Marvisi, Pamela Mancuso, Roberto Farì, Filippo Monelli, Matteo Revelli, Rexhep Durmo, Elena Galli, Francesco Muratore, Lucia Spaggiari, Marta Ottone, Stefano Luminari, Pierpaolo Pattacini, Paolo Giorgi Rossi, Carlo Salvarani
来源: Experimental Hematology & Oncology

摘要:

本研究的目的是比较大血管炎(LVV)患者和淋巴瘤患者(作为没有LVV的人群参照)CT扫描评估的动脉壁钙化的患病率、实体和局部分布。包括2007年至2019年之间进行基线正电子发射断层扫描-CT(PET-CT)的LVV患者在内的所有连续诊断为LVV的患者都被纳入研究;非LVV患者是按照年龄(±5岁)、性别和基线PET-CT年份(≤2013、>2013)匹配的淋巴瘤患者。对两组患者的基线PET-CT扫描产生的CT图像进行了单一放射科医师的回顾研究,经过设置最低130 Hounsfield单位的阈值后,半自动计算了三个不同位置(冠状动脉、胸部动脉和腹部动脉)的血管钙化,以Agatston和体积得分量化。共纳入了266名患者。腹部动脉钙化的分布相当(LVV组为平均3220,淋巴瘤组为平均2712)。年龄和诊断年份调整后,LVV组与胸部钙化的存在有关(OR 4.13,95% CI 1.35到12.66;p=0.013)。同样,LVV组与胸部动脉的体积得分显著相关(p=0.048)。在50岁以上的患者中,冠状动脉钙化在非LVV患者中更为广泛(体积p=0.027)。与没有LVV的患者相比,LVV患者在胸部动脉中具有更高的钙化程度,但在冠状动脉和腹部动脉中没有更高的钙化程度。©作者(或其雇主)2023。在CC BY-NC许可下允许再使用。无商业再利用。由BMJ出版。
The aim of this study was to compare the prevalence, entity and local distribution of arterial wall calcifications evaluated on CT scans in patients with large vessel vasculitis (LVV) and patients with lymphoma as reference for the population without LVV.All consecutive patients diagnosed with LVVs with available baseline positron emission tomography-CT (PET-CT) scan performed between 2007 and 2019 were included; non-LVV patients were lymphoma patients matched by age (±5 years), sex and year of baseline PET-CT (≤2013; >2013). CT images derived from baseline PET-CT scans of both patient groups were retrospectively reviewed by a single radiologist who, after setting a threshold of minimum 130 Hounsfield units, semiautomatically computed vascular calcifications in three separate locations (coronaries, thoracic and abdominal arteries), quantified as Agatston and volume scores.A total of 266 patients were included. Abdominal artery calcifications were equally distributed (mean volume 3220 in LVVs and 2712 in lymphomas). Being in the LVVs group was associated with the presence of thoracic calcifications after adjusting by age and year of diagnosis (OR 4.13, 95% CI 1.35 to 12.66; p=0.013). Similarly, LVVs group was significantly associated with the volume score in the thoracic arteries (p=0.048). In patients >50 years old, calcifications in the coronaries were more extended in non-LVV patients (p=0.027 for volume).When compared with patients without LVVs, LVVs patients have higher calcifications in the thoracic arteries, but not in coronary and abdominal arteries.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.