二甲双胍和阿司匹林可降低前庭神经鞘瘤（VS）的生长。已有报道表明，服用二甲双胍的VS患者与肿瘤体积的减少有关。动物实验也表明，阿司匹林可减缓VS的生长。我们在50只无胸腺裸鼠体内培养和植入大鼠神经鞘瘤细胞株。将肿瘤培养至5毫米，然后每天注射低剂量或高剂量的二甲双胍、阿司匹林或生理盐水。直到经过14天或老鼠出现溃疡、行走困难或死亡等症状为止，我们测量了肿瘤的大小。控制组和治疗组之间的初始肿瘤大小没有显著差异（p = 0.73）。在低剂量组（但不是高剂量组），二甲双胍（p = 0.04）和阿司匹林（p = 0.02）的第7天体积与安慰剂组相比有显着差异。盐水组的平均肿瘤生长速率为126.6 ± 65.6 mm3/天，而低剂量二甲双胍组为73.7 ± 29.5 mm3/天（p = 0.03），低剂量阿司匹林组为68.7 ± 34.8 mm3/天（p = 0.016）。低剂量二甲双胍组和低剂量阿司匹林组的肿瘤大小（p = 0.59）和生长速率（p = 0.75）之间无显着差异。低剂量组在14天后停止治疗，继续监测结果显示，阿司匹林（p = 0.006）和二甲双胍（p = 0.048）未治疗肿瘤生长显著增加。二甲双胍治疗可将VS的生长显著降低至与阿司匹林相似的水平。此外，当停用二甲双胍和阿司匹林治疗时，肿瘤生长显著增加。版权所有 © 2023年，《听力学与神经学》。

Metformin and aspirin reduce vestibular schwannoma (VS) growth.There have been reported associations between patients with VS prescribed metformin and decreased tumor volumetric growth. Aspirin has also been associated with decreased VS growth in animal studies.Rat schwannoma cell lines were grown and implanted into 50 athymic nude mice. Tumors were grown to 5 mm, and then mice were injected with either low- or high-dose metformin, aspirin, or saline daily. Tumors were measured until 14 days elapsed or mice demonstrated symptoms such as ulceration, inability to walk, or passed away.There were no significant differences in day 0 tumor sizes between the control and the treatment groups (p = 0.73). In the low-dose, but not high-dose groups, day 7 volumes were significantly different for both metformin (p = 0.04) and aspirin (p = 0.02) compared with placebo. Mean tumor growth rates were 126.6 ± 65.6 mm3/day for saline compared with 73.7 ± 29.5 mm3/day for low-dose metformin (p = 0.03) and 68.7 ± 34.8 mm3/day for low-dose aspirin (p = 0.016). There were no significant differences in tumor sizes (p = 0.59) or growth rates (p = 0.75) between low-dose metformin and aspirin groups. Low-dose groups had treatment stopped at 14 days, with continued monitoring demonstrating significant increases in tumor growth off treatment for both aspirin (p = 0.006) and metformin (p = 0.048).Metformin treatment significantly reduced VS growth to a similar level as aspirin. Furthermore, when removing both metformin and aspirin treatment, tumor growth significantly increased.Copyright © 2023, Otology & Neurotology, Inc.