本研究的目的是确定基因决定的饮酒量与重大癌症发生之间的因果关系。本研究使用的数据来自于韩国癌症预防研究-II，选择了129324名参与者，他们在2004年至2013年间参观了18个健康检查中心。癌症发生率数据截至2020年，来源于国家癌症中心。使用PLINK 2.0进行了一项基因组关联研究（GWAS），并根据性别、年龄、芯片类型和主成分进行了调整。从GWAS中，计算了用于饮酒量的遗传风险评分，并估计了基因决定的饮酒量（GDAC）。将GDAC分为五个分位组，并显示了与直肠癌和肝癌的显著因果关系，但与其他癌症无关。对于肝癌而言，在乙肝表面抗原（HBsAg）阴性群体中显示了一定的关联，并在年龄超过60岁的HBsAg阴性群体中发现了特别强的关联，与GDAC Q1组相比，Q4组的风险增加了2.35倍（95% CI，1.05-5.23），Q5组则增加了2.40倍（95% CI，1.22-7.01）。本研究结果为证明所饮酒的数量与HBsAg阴性的患者患直肠癌和肝癌之间具有因果关系提供了证据。应继续进行其他癌症类型的长期跟踪研究。

The purpose of this study was to determine the causal relationship between the genetically determined amount of alcohol consumption and the occurrence of major cancers.The data used in this study were from 129,324 people selected from the Korean Cancer Prevention Study-II, the participants of which visited 18 health examination centers between 2004 and 2013. Cancer incidence was confirmed as of 2020 using data from the National Cancer Center. A genome-wide association study (GWAS) on alcohol consumption was performed using PLINK 2.0, and sex, age, chip type, and principal components were adjusted.From the GWAS, a genetic risk score for alcohol consumption was calculated and genetically determined alcohol consumption (GDAC) was estimated. GDAC was divided into quintile groups and showed significant causal relationships with rectal cancer and liver cancer, but not with other cancers. For liver cancer, an association was shown in the hepatitis B surface antigen (HBsAg)-negative group, and a particularly strong association was found in the over-60-year-old HBsAg-negative group, in which, compared to the GDAC Q1 group, the Q4 group had a 2.35 times higher risk (95% CI, 1.05-5.23), and the Q5 group had a 2.40 times higher risk (95% CI, 1.22-7.01).The results of this study provided evidence that the amount of alcohol consumed is causally related to the occurrence of rectal cancer and liver cancer in HBsAg-negative individuals. Additional studies should be continued for other cancer types through long-term follow-up.