局部胃肠道（GI）癌症患者中越来越多地使用新辅助治疗（NT）。目前很少有数据评估NT期间GI癌症患者的体验和生活质量（QOL）。为了使用定制的智能手机应用程序来前瞻性测量NT期间的QOL和实时患者体验。接受NT的GI癌症患者通过定制的智能手机应用程序接受基线、每30天一次和NT完成时的健康相关（HR）QOL的验证评估癌症治疗功能（FACT-G）问卷的指导。参与者还在应用程序中追踪他们的情绪、症状，并使用自由文本日志功能。在NT期间计算平均整体和子部分HRQOL得分。在104名入组患者中，平均年龄为60.5±11.5岁，55%为男性。常见的癌症诊断为结直肠癌（40%）、胰腺癌（37%）和食管癌（15%）。NT期间的平均整体FACT-G得分没有变化（P=0.987）。虽然功能幸福得分一直是最低的，社交幸福得分最高，但FACT亚分得分在NT期间也没有变化（所有P>0.01）。NT期间报告的最常见症状是疲劳、失眠和焦虑（分别为39.3%、34.5%和28.3%的患者记录）。自由文本日志条目的定性分析确定了焦虑、恐惧和挫折感是最常见的主题，但也强调了社会支持系统的重要性和对医疗提供者的信任。虽然患者症状负担仍然很高，但这项前瞻性队列研究的结果表明，在局部GI癌症的NT期间，QOL保持不变。版权所有©2023 Wolters Kluwer Health, Inc. 保留所有权利。

Neoadjuvant therapy (NT) is increasingly used for patients with localized gastrointestinal (GI) cancers. There is little data assessing patient experience and quality of life (QOL) during NT for GI cancers.To use a customized smartphone application to prospectively measure QOL and the real-time patient experience during NT.Patients with GI cancers receiving NT were instructed on using a customized smartphone application through which the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire, a validated measure of health-related (HR) QOL, was administered at baseline, every 30 days, and at completion of NT. Participants also tracked their mood, symptoms, and used free-text journaling functionalities in the application. Mean overall and sub-section HRQOL scores were calculated during NT.Among 104 enrolled patients, mean age was 60.5±11.5 years and 55% were male. Common cancer diagnoses were colorectal (40%), pancreatic (37%), and esophageal (15%). Mean overall FACT-G scores did not change during NT (P=0.987). While functional wellbeing scores were consistently the lowest and social wellbeing scores the highest, FACT subscores similarly did not change during NT (all P>0.01). The most common symptoms reported during NT were fatigue, insomnia, and anxiety (39.3%, 34.5%, and 28.3% of patient entries, respectively). Qualitative analysis of free-text journaling entries identified anxiety, fear, and frustration as the most common themes, but also the importance of social support systems and confidence in health care providers.While patient symptom burden remains high, results of this prospective cohort study suggest QOL is maintained during NT for localized GI cancers.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.