本研究旨在探究不同终端木提取物对不同癌细胞系增殖的潜在抑制活性。通过液-液萃取过程分离，使用增强极性溶剂（如正己烷、氯仿、乙酸乙酯和水）获得了四种不同的分馏物。利用SRB测定了所有提取物对癌细胞系的细胞毒性，并利用流式细胞仪对其对细胞周期相的抑制活性进行了测试。氯仿提取物对所有三种癌细胞系，特别是HepG2细胞，在100 µg浓度下呈现出细胞毒性作用。此外，氯仿、乙酸乙酯和正己烷等最显著的植物提取物在S期细胞周期中显著诱导细胞死亡。该研究的结果表明，沙特传统医学中使用的终端木植物中的化合物可能具有抑制癌细胞系生长的潜力。

The present study aimed to investigate the potential inhibitory activities of various Terminalia brownie extracts against the proliferation of different cancer cell lines. Fractionation was carried out through the process of liquid-liquid extraction produced four fraction types using polarity-enhancing solvents such as, n-hexane, chloroform, ethyl acetate, and water. All extracts have been tested for their cytotoxicity against cancer cell lines using SRB assay and their inhibitory activity on cell cycle phases using flow cytometry. The chloroform extract exhibited a cytotoxic effect against all three types of cancer cell lines and especially the HepG2 cells at 100-µg concentration. Moreover, the most prominent plant extracts of chloroform, acetyl acetate, and hexane showed significant induction of cell death during the S phase cell cycle. The findings of this study suggest that compounds in the Terminalia brownie plant used in traditional Saudi medicine may have the potential to suppress the growth of cancer cell lines.