疾病如子宫平滑肌瘤（子宫良性肿瘤）和瘢痕疙瘩（凸起疤痕）可能具有共同的病因。子宫瘤和瘢痕疙瘩可以在个体中共同出现，两者都具有高度的遗传性，表明它们可能共享相同的遗传风险因素。纤维增生性疾病常见，其特点是瘢痕和结缔组织过度生长，影响多个器官系统。这些疾病都存在种族差异的患病率，其中以非洲人的患病率最高。一些纤维增生性疾病在撒哈拉以南非洲的人群中更为严重和常见。本综述旨在概述当前对纤维增生性疾病的进化起源和原因的了解。我们还讨论了目前的假设，即非洲衍生人群中这些疾病患病率增加是由于选择保护性纤维增生等位基因对抗寄生虫感染，并提供了子宫肌瘤和瘢痕疙瘩研究的实例。

Diseases such as uterine leiomyomata (fibroids, benign tumors of the uterus) and keloids (raised scars) may share common etiology. Fibroids and keloids can co-occur in individuals, and both are highly heritable, suggesting they may share common genetic risk factors. Fibroproliferative diseases are common and characterized by scarring and overgrowth of connective tissue, impacting multiple organ systems. These conditions both have racial disparities in prevalence, with highest prevalence observed among individuals of African ancestry. Several fibroproliferative diseases are more severe and common in populations of sub-Saharan Africa. This mini-review aims to provide a broad overview of the current knowledge of the evolutionary origins and causes of fibroproliferative diseases. We also discuss current hypotheses proposing that the increased prevalence of these diseases in African-derived populations is due to selection for pro-fibrotic alleles that are protective against helminth infections and provide examples from knowledge of uterine fibroid and keloid research.