头颈鳞状细胞癌是一类解剖学和功能学上复杂的恶性肿瘤。其显著的局部侵袭性和频繁的局部复发促使着对于更可靠和敏感的预测和预测性生物标志物的持续研究。肿瘤滋养在各种类型上皮癌侵袭前缘的评估是癌症生物学的一个新兴领域。近期研究表明，肿瘤滋养在癌症进展中是相对常见的现象，其可能对患者具有重要的预后影响，因为它有潜力为头颈癌的生物学和临床行为提供宝贵的见解。在本综述中，我们旨在提供关于头颈鳞状细胞癌中肿瘤滋养的信息，以此让我们能够对这些恶性肿瘤的复杂生物学有更清晰的认识，同时有助于诊断、分类、更好地表征，以寻找改善患者结果的新途径。© 2023年，作者，独家授权给德国施普林格 - 德国施普林格出版集团一部分的施普林格性质出版公司。

Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and frequent regional relapses motivate ongoing research to identify more reliable and sensitive prognostic and predictive biomarkers. One emerging area of cancer biology is the evaluation of tumor budding at the advancing invasive front of various types of epithelial cancers. Recent studies suggest that tumor budding is a relatively common phenomenon in cancer progression and that it may have important prognostic implications for patients due to its potential to provide valuable insights into the biology and clinical behavior of head and neck cancer. In this review, we aim to provide information about tumor budding in head and neck squamous cell carcinoma. Thus, we hope to shed light on the complex biology of these malignancies, as well as aiding diagnostic, classification, and better characterization and thereby, looking for new avenues for improving patient outcomes.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.