在COVID-19患者长时间住院ICU（重症监护病房）后，结果是否值得？令人惊讶的是，大规模队列中关于长期死亡率的数据是缺乏的。我们调查了长期死亡率，包括男性和女性之间的差异，因为先前的研究表明，男性在疾病严重程度和短期死亡率方面通常比女性更严重。瑞典ICU接收的所有成年COVID-19患者的全国队列，截止到2022年8月12日。主要观测指标是ICU入院后360天的死亡率。使用逻辑回归估计人口统计学特征、共病疾病、临床特征与死亡之间的关联。总共包括8392名患者。中位年龄（IQR）为63（52-72）岁，大多数（70.1%）为男性。在完整记录360天死亡率数据的7390名患者中，有1775名（24.4%）在30天内死亡，2125名（28.8%）在90天内死亡，2206名（29.8%）在ICU入院后的360天内死亡。女性的360天死亡率为27.1%，男性为31.0%。多变量逻辑回归分析显示，与女性相比，男性患者有较高的360天死亡风险（OR: 1.33, 95% CI: 1.17-1.52）。与较差的360天死亡率相关的其他变量包括年龄、心脏疾病、COPD/哮喘、糖尿病、免疫缺陷、慢性肾脏疾病、神经肌肉疾病和恶性肿瘤。该研究证实了COVID-19重症男性患者在长期视角下疾病的严重程度增加。然而，90天后的死亡率非常低，这意味着急性病程后存活的可能性很高。© 2023. La Société de Réanimation de Langue Francaise = The French Society of Intensive Care (SRLF).

Was it worth it-what is the outcome after the extended ICU (intensive care unit) length of stay for COVID-19 patients? Surprisingly, data on long-term mortality in large cohorts are lacking. We investigate long-term mortality including differences between men and women, as previous studies show that men generally suffer a more severe course of COVID-19 in terms of severity of illness and short-term mortality.Nationwide cohort including all adult COVID-19 patients admitted to Swedish ICUs until August 12, 2022. Primary outcome was 360-day mortality after ICU admission. Logistic regression was used to estimate associations between demographics, comorbidities, clinical characteristics and mortality.In total, 8392 patients were included. Median (IQR) age was 63 (52-72) years and the majority (70.1%) were men. Among the 7390 patients with complete 360-day mortality data, 1775 (24.4%) patients died within 30 days, 2125 (28.8%) within 90 days and 2206 (29.8%) within 360 days from ICU admission. 360-day mortality was 27.1% in women and 31.0% in men. Multivariable logistic regression analysis showed increased risk of 360-day mortality in men compared to women (OR: 1.33, 95% CI: 1.17-1.52). Other variables associated with poor 360-day mortality were age, cardiac disease, COPD/asthma, diabetes, immune deficiency, chronic kidney disease, neuromuscular disease, and malignancy.This study confirms the increased severity of disease in critically ill men with COVID-19, even in a long-term perspective. However, mortality beyond 90 days was strikingly low, indicating high probability of survival after the acute phase of illness.© 2023. La Société de Réanimation de Langue Francaise = The French Society of Intensive Care (SRLF).