报告一例接受高利莫单抗（肿瘤坏死因子-α抑制剂）慢性免疫抑制治疗的少年特发性关节炎患者，发生Cladosporium sphaerospermum引起的真菌内源性眼内炎。病例报告和文献综述。一名34岁的女性患者因单侧视力下降和眼部疼痛而被转诊。在皮质类固醇治疗后病情恶化和升高的血清β-D-葡聚糖水平提示存在真菌感染病因。通过玻璃体切割术获取的玻璃体标本进行全真菌聚合酶链反应基因测序检测出C. sphaerospermum。患者的治疗采用了手术治疗以及全身和眼内注射伏立康唑。真菌内源性眼内炎可能是患者接受慢性免疫抑制治疗（包括高利莫单抗）的罕见并发症，无其他易感因素。及时确诊和适当治疗是保护视力的关键。

To report a case of fungal endogenous endophthalmitis from Cladosporium sphaerospermum in a patient with juvenile idiopathic arthritis receiving chronic immunosuppressive therapy with golimumab (tumor necrosis factor-α blocker).Case report and review of the literature.A 34-year-old woman receiving chronic immunosuppressive therapy with golimumab for juvenile idiopathic arthritis was referred for unilateral visual loss and ocular pain. Worsening conditions after corticosteroid therapy and raised serum beta-D-glucan levels pointed to an infectious fungal etiology. Panfungal polymerase chain reaction-based genetic sequencing on vitreous specimens obtained during vitrectomy detected C. sphaerospermum. The patient management combined surgical treatment and systemic and intravitreal voriconazole.Endogenous fungal endophthalmitis can be a rare complication in patients undergoing chronic immunosuppressive therapy (including golimumab) without other predisposing factors. Prompt diagnosis and appropriate treatment are the keys to preserve vision.