溶酶体在调节各种癌症的发展和转移中起着关键作用。目前迫切需要溶酶体碱化剂，可以选择性和安全地改变癌症溶酶体的pH值，抑制其功能。在这里，我们报道了一种有效、选择性和安全的溶酶体碱化剂，可以抑制自噬并抑制小鼠肿瘤的生长。我们的溶酶体碱化剂由Fex Oy核心和CeO2-z卫星组成，核心在癌症溶酶体内的过量H+和H2 O2存在下产生羟基自由基(•OH)，卫星则捕获并将•OH转化为羟离子(OH-)。碱化的溶酶体显示了受损的酶活性和自噬，导致癌细胞的凋亡。我们展示了我们的碱化剂在小鼠体内有效抑制了局部和全身肿瘤的生长和转移。我们的工作表明，纳米颗粒的固有特性可以用来构建既选择性又安全的有效溶酶体碱化剂。本文受版权保护，保留所有权利。

Lysosomes are critical in modulating the progression and metastasis for various cancers. There is currently an unmet need for lysosomal alkalizers that can selectively and safely alter the pH and inhibit the function of cancer lysosomes. Here we report an effective, selective, and safe lysosomal alkalizer that can inhibit autophagy and suppress tumors in mice. Our lysosomal alkalizer consists of an Fex Oy core that generates hydroxyl radicals (•OH) in the presence of excessive H+ and H2 O2 inside cancer lysosomes and CeO2-z satellites that capture and convert •OH into hydroxide ions (OH- ). Alkalized lysosomes, which display impaired enzyme activity and autophagy, lead to cancer cell apoptosis. We show that our alkalizer effectively inhibited both local and systemic tumor growth and metastasis in mice. Our work demonstrates that the intrinsic properties of nanoparticles can be harnessed to build effective lysosomal alkalizers that are both selective and safe. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.