胶质母细胞瘤（GBM）是最具侵袭性的胶质瘤类型（四级）。细胞毒性T淋巴细胞（CTLs）的存在与GBM患者的疗效改善相关，并且人们认为树突状细胞通过激活CTLs可能对GBM的生长控制起到关键作用。树突状细胞是专业的抗原呈递细胞（APC），协调先天性和适应性的抗GBM免疫反应。树突状细胞可以根据环境暴露分化为浆细胞样树突状细胞（pDC）、常规型树突状细胞1（cDC1）、常规型树突状细胞2（cDC2）和单核细胞源性树突状细胞（moDC）。不同亚群的树突状细胞在抗原呈递和T细胞激活方面具有不同的功能能力，以产生抗肿瘤反应。本综述主要关注近期研究对人类树突状细胞亚群的表型和功能特征以及它们在GBM相关微环境中的抗肿瘤免疫和免疫耐受角色的描述。本综述还针对最新文献，重点介绍了树突状细胞亚群之间的相互作用对GBM特异性免疫反应所起到的重要作用。由于树突状细胞可能是治疗干预的首要靶点，因此总结树突状细胞亚群与GBM相关免疫耐受性及其治疗潜力的相关性是值得的。版权所有 © 2023。由Elsevier B.V出版。

Glioblastoma (GBM) is the most aggressive type of glioma (Grade IV). The presence of cytotoxic T lymphocyte (CTLs) has been associated with improved outcomes in patients with GBM, and it is believed that the activation of CTLs by dendritic cells may play a critical role in controlling the growth of GBM. DCs are professional antigen-presenting cells (APC) that orchestrate innate and adaptive anti-GBM immunity. DCs can subsequently differentiate into plasmacytoid DCs (pDC), conventional DC1 (cDC1), conventional (cDC2), and monocyte-derived DCs (moDC) depending on environmental exposure. The different subsets of DCs exhibit varying functional capabilities in antigen presentation and T cell activation in producing an antitumor response. In this review, we focus on recent studies describing the phenotypic and functional characteristics of DC subsets in humans and their respective antitumor immunity and immunotolerance roles in the GBM-associated microenvironment. The critical components of crosstalk between DC subsets that contribute significantly to GBM-specific immune responses are also highlighted in this review with reference to the latest literature. Since DCs could be prime targets for therapeutic intervention, it is worth summarizing the relevance of DC subsets with respect to GBM-associated immunologic tolerance and their therapeutic potential.Copyright © 2023. Published by Elsevier B.V.