用于鉴别癌细胞和正常细胞以及诊断脂肪肝的脂滴特异性近红外荧光探针。
Lipid droplet-specific near-infrared fluorescent probe for discriminating cancer and normal cells and diagnosing fatty liver.
发表日期：2023 Aug 22
作者：
Yuehua Zhang, Han Zhao, Junshuai Tang, Shiyu Nan, Liqing Lu, Pingzhu Zhang, Chao Wei
来源：
BIOORGANIC CHEMISTRY
摘要：
脂质滴（LDs）是一种新的重要细胞器，参与多种生理和病理过程。LDs被视为潜在的疾病诊断标志物。特异性成像LDs有助于理解其基本生物功能以及诊断疾病。在此，我们设计并合成了两种基于LDs低极性和高粘度的荧光探针。终端探针ZH-2表现出亲脂性、近红外发射，粘度敏感性和LDs特异性。该探针已成功用于可视化LDs代谢、区分正常细胞和癌细胞以及诊断脂肪肝病。版权所有©2023 Elsevier Inc. 保留所有权利。
Lipid droplets (LDs) is a newly essential organelle, which participates in carious physiological and pathological processes. LDs are considered as potential markers for disease diagnosis. Specific imaging of LDs is useful to understand their basic biological function and to diagnose diseases. Here we designed and synthesized two fluorescent probes based on the low polarity and high viscosity in LDs. The terminal probe ZH-2 exhibits lipophilicity, NIR emission, viscosity sensitivity, and LDs specificity. The probe has been successfully used for visualizing LDs metabolism, discriminating between normal and cancerous cells, and diagnosing fatty liver disease.Copyright © 2023 Elsevier Inc. All rights reserved.