为了评估在早期乳腺癌患者治疗后，集体体育锻炼项目对健康相关生活质量（HRQOL）、体能和活动以及安全性的影响，设计了一个双阶段试验（16周控制阶段（CP）后跟一个16周干预阶段（IP））。结果在基线（T1）、8（T2）和16（T3）周（CP）以及24（T4）和32（T5）周（IP）进行评估。主要终点是全局健康状况。由82名入组患者中，37名完成了IP。全局健康状况在CP期间下降（-10.1，95% CI -19.8 to -0.4；p = 0.040），在IP期间稳定。在IP期间，体能和性功能提高（p = 0.008；p = 0.017），而心肺功能在CP期间提高（p = 0.004）。上肢力量和下肢功能在两个阶段都有提高（CP：p < 0.0001，p = 0.001（手术和非手术侧），p = 0.028）；IP：p < 0.0001， p = 0.002，p = 0.009）。体重指数在IP期间降低（p = 0.026）。腰围在CP期间增加（p = 0.001），在IP期间减少（p = 0.010）；久坐行为和中等及高强度体育活动没有改变。54%的患者报告达到70%的参加次数。没有报告与干预措施有关的严重不良事件。综上所述，体育锻炼项目能够防止全局健康状况的下降，并改善HRQOL和体能的其他领域。由于体育锻炼在许多国家并不是标准护理，因此集体体育课程的实施可能是一种选择。

To assess the effects of a group class physical exercise program on health-related quality of life (HRQOL), physical fitness and activity, and safety in early breast cancer women after treatment, a double-phase trial [16-week control phase (CP) followed by a 16-week intervention phase (IP)] was designed. Outcomes were evaluated at baseline (T1), 8 (T2) and 16 (T3) weeks (CP), and 24 (T4) and 32 (T5) weeks (IP). The primary endpoint was global health status. Out of 82 enrolled patients, 37 completed the IP. Global health status decreased (-10,1; 95% CI -19.8 to -0.4; p = 0.040) during the CP and stabilized during the IP. Physical and sexual functioning increased during the IP (p = 0.008; p = 0.017), while cardiorespiratory fitness increased in the CP (p = 0.004). Upper limb strength and lower limb functionality increased during both phases [CP: p < 0.0001, p = 0.001 (surgical and nonsurgical arm), p = 0.028; IP: p < 0.0001, p = 0.002, p = 0.009]. Body mass index decreased in the IP (p = 0.026). Waist circumference increased in the CP (p = 0.001) and decreased in the IP (p = 0.010); sedentary behaviours and moderate and vigorous physical activity did not change. Adherence to 70% of the sessions was reported in 54% of patients. No serious adverse events related to the intervention were reported. In conclusion, the physical exercise program was able to prevent the decline in global health status and to improve other domains of HRQOL and physical fitness. As physical exercise is not the standard of care in many countries, the implementation of group class programs might be an option.