犬色素性病毒斑（PVPs）是由犬乳头瘤病毒（CPVs）引起的增生性表皮病变。尽管这些病变是良性的，但恶性转化的报道有所增加。文献中报道的案例很少，主要集中在基因组测序方面。本研究的目的是收集有关PVPs的流行病学、临床病理特征和基因分型的数据。回顾性检索了55例犬PVPs并进行了组织学评价。有33例病例有随访。中位年龄为6.5岁，哈巴狗是最常见的品种（25%）。有4种临床表现：单个病变（24%），多个病变（75%）在一个（41%）或不同部位（34%），以及全身泛发病变（24%）。腹部和腋窝是最常见的部位。在单个病变中，常规手术后未观察到复发，而对于多个病变报告的不同医疗方法并不成功。有3例报告了自发性消退。在55个病变中，有5个（9%）与PVPs相邻的肿瘤病变，并有1只狗因浸润性鳞状细胞癌（SCC）而安乐死。用于诊断的最有用的组织病理学特征是波浪状轮廓、表皮刺、过度颗粒化和过度色素沉着。16例中的14例（87%）存在L1免疫标记。测序显示，16例中有10例与CPV-9相关（71%），2例与CPV-4相关（14%），2例与CPV-8相关（14%）。总之，这是意大利首次报道的有关犬PVPs的临床病理特征、治疗、预后和涉及的CPV类型的大型队列研究。

Canine pigmented viral plaques (PVPs) are proliferative epidermal lesions caused by canine papillomaviruses (CPVs). Although the lesions are benign, neoplastic transformation has been reported. Cases reported in the literature are few and mainly focused on genome sequencing. The aim of this study was to collect data on the epidemiology, clinicopathological features, and genotyping of PVPs. Fifty-five canine PVPs were retrospectively retrieved and histologically evaluated. Follow-up was available for 33 cases. The median age was 6.5 years and pugs were the most represented breed (25%). There were 4 clinical presentations: a single lesion (24%), multiple lesions (75%) in one (41%) or different sites (34%), and generalized lesions all over the body (24%). The abdomen and axillae were the most common sites. In single lesions, no recurrence was observed after conventional surgery, whereas different medical treatments reported for multiple lesions were not successful. Spontaneous regression was reported in 3 cases. Neoplasia in contiguity with PVPs was seen in 5 of 55 lesions (9%), and 1 dog was euthanized due to invasive squamous cell carcinoma (SCC). The most useful histopathological features for diagnosis were scalloped profile, epidermal spikes, hypergranulosis, and hyperpigmentation. L1 immunolabeling was present in 14 of 16 cases (87%). Sequencing revealed that 10 of 16 cases were associated with CPV-9 (71%), 2 cases were associated with CPV-4 (14%), and 2 cases were associated with CPV-8 (14%). In conclusion, this represents a large cohort study on canine PVPs reporting data on clinicopathological features, therapy, outcome, and the type of CPV involved for the first time in Italy.