目标：克罗恩病（CD）是一种无法治愈的慢性疾病，需要长期治疗。英夫利昔单抗（IFX）作为一种抗肿瘤坏死因子（TNF）药物，在克罗恩病的治疗中被广泛使用，然而患者的依从性不高。本研究旨在调查中国CD患者对IFX的依从性，并评估药物信念与IFX依从性之间的关联。方法：通过在线问卷和电子病历（EMR）收集人口统计学数据、临床信息和患者的药物信念。使用药物信念问卷（BMQ-specific）评估药物信念，包括BMQ-specific关注分数和BMQ-specific必要性分数。使用单变量和多元逻辑回归分析评估依从性因素。结果：总共有166名CD患者回答了在线问卷，其中77名（46.39%）患者具有高依从性。低依从性患者的BMQ-specific关注分数为30.00，高依从性患者为27.50，BMQ-specific关注分数更低的患者依从性更高（p = 0.013）。多元回归分析显示，BMQ-specific关注分数（OR = 0.940, 95% CI: 0.888-0.996）在CD患者中显著影响IFX的依从性。此外，性别、婚姻状况、途中耗时（包括输液中心的等待时间）和适应中心的情况也是影响依从性的因素。结论：中国CD患者对IFX的依从性不高。药物关注可能是依从性的预测因素。教育、IFX治疗的持续时间和不良反应经验与IFX的依从性没有显著相关性。通过增加知识和缓解药物担忧，可以提高患者对IFX的依从性。Copyright © 2023 Li, Ma, Sun, Ni, Hu, Chen and Lan.

Objective: Crohn's disease (CD) is an incurable chronic disease that requires long-term treatment. As an anti-tumor necrosis factor (TNF) agent, Infliximab (IFX) is widely used in the treatment of Crohn's disease, while the adherence is not high. The purpose of this study was to investigate the adherence to IFX among CD patients in China and evaluate the association between medication belief and IFX adherence. Methods: Demographic data, clinical information and patients' medication beliefs were collected using an online questionnaire and reviewing electronic medical records (EMRs). The Beliefs about Medicines Questionnaire (BMQ)-specific was used to assess medication beliefs which contains the BMQ-specific concern score and the BMQ-specific necessity score. An evaluation of adherence factors was conducted using univariate and multidimensional logistic regression analyses. Results: In all, 166 CD patients responded the online questionnaire among which 77 (46.39%) patients had high adherence. The BMQ-specific concern score in patients in low adherence was 30.00 and in high adherence patients was 27.50, and patients with lower BMQ-specific concern score had higher adherence (p = 0.013). The multiple regression analysis showed that the BMQ-specific concern score (OR = 0.940, 95% CI: 0.888-0.996) significantly affected the IFX adherence in CD patients. Otherwise, gender, marital status, time spent on the way (including the waiting time in infusion center) and accommodation to the center were also the influencing factors of adherence. Conclusion: The IFX adherence to CD in China was not high. Medicine concerns may be predictive factor of adherence. Education, the duration of IFX therapy and experience of adverse effects were not significantly associated with IFX adherence. By enhancing knowledge and relieving medicine concerns, we may increase patients' adherence to IFX.Copyright © 2023 Li, Ma, Sun, Ni, Hu, Chen and Lan.