来源于髓系的抑制性细胞(MDSCs)是一种异质性髓系细胞群体，对肿瘤微环境起着重要作用。反应性氧化物(ROS)是有氧呼吸的副产物，参与调节正常生物活动和疾病进展。MDSCs能够产生ROS以满足其免疫抑制活性，并通过氧化还原系统清除过量ROS以保证其良好的存活。本综述重点介绍了MDSCs在高水平ROS中生存和功能的机制，并总结了针对MDSCs中ROS的免疫治疗方法。ROS在MDSCs中的独特作用将启发我们广泛应用阻断氧化应激策略来针对MDSC治疗在未来临床治疗中的应用。版权所有 © 2023 黄、赵、赵、印和王。

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous myeloid cell population and serve as a vital contributor to the tumor microenvironment. Reactive oxygen species (ROS) are byproducts of aerobic respiration and are involved in regulating normal biological activities and disease progression. MDSCs can produce ROS to fulfill their immunosuppressive activity and eliminate excessive ROS to survive comfily through the redox system. This review focuses on how MDSCs survive and function in high levels of ROS and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.Copyright © 2023 Huang, Zhao, Zhao, Yin and Wang.