蓝藻蛋白胆蓝蛋白（phycocyanin）是由螺旋藻生产的一种具有抗炎、抗高痛感、抗氧化、抗肿瘤和抗癌特性的活性物质。然而，由于胃酸pH条件下的不稳定性，胆蓝蛋白在体内的摄取常常受到阻碍。纳米药物输送系统已经发展成为一种有希望的高效输送药物、改良药物效力的平台。细菌纤维素纳米晶体（BCNC）由于其固有的纳米级尺寸、大的表面积以及生物相容性和无毒性等特性具有优越性作为DDS。为了改善其机械性能，BCNC被戊二醛交联，并作为DDS的潜在候选物进行了分析。红外光谱分析结果显示，水解并没有改变BCNC的化学组成。BCNC的结晶度指数比原始BC高出了18.31%，表明结晶纤维素已成功分离。BCNC颗粒还呈现出针状的形态，直径为25±10nm，平均长度为626±172nm。交联的BCNC孔径比原始BCNC更大，热稳定性也更高。在3小时内，交联的BCNC对胆蓝蛋白的最佳吸附率达到了65.3%。释放研究表明，交联的BCNC能够保护胆蓝蛋白在胃液中的缓慢释放，直到胆蓝蛋白到达目标部位。本研究提供了一种来源于自然生物资源的潜在替代DDS，具有更低的开支和更好的性能，促进了BCNC作为生物医学科学中功能性纳米材料的应用。

Phycocyanin, produced by Spirulina platensis, has been reported as an anti-inflammatory, anti-hyperalgesia, antioxidant, anti-tumor, and anti-cancer agent. However, the ingestion of phycocyanin in the body is often hindered by its instability against gastric pH conditions. The nano-drug delivery system has developed as a promising platform for efficient drug delivery and improvement as well as drug efficacy. Bacterial cellulose nanocrystal (BCNC) has it superiority as DDS due to its inherent properties such as nanoscale dimension, large surface area, - biocompatibility, and non-toxic. To improve its mechanical properties, BCNC was crosslinked with glutaraldehyde and was analyzed as a potential candidate for DDS. The Fourier transform infrared analysis of the BCNC suggested that hydrolysis did not alter the chemical composition. The index of crystallinity of the BCNC was 18.31% higher than that of the original BC, suggesting that crystalline BC has been successfully isolated. The BCNC particle also showed a needle-like morphology which is 25 ± 10 nm in diameter and a mean length of 626 ± 172 nm. Crosslinked BCNC also had larger pores than the original BCNC along with higher thermal stability. Optimum phycocyanin adsorption on crosslinked BCNC reached 65.3% in 3 h. The release study shows that the crosslinked BCNC can protect the phycocyanin retardation by gastric fluid until phycocyanin reaches the targeted sites. This study provides an alternative potential DDS derived from natural bioresources with less expenses and better properties to promote the application of BCNC as functional nanomaterials in biomedical science.