恶性肿瘤的特点之一是细胞生长、分裂和增殖失控，因而可被广泛描述为异质性疾病。肿瘤细胞利用代谢重编程来满足维持其失控生长、增殖和存活所需的营养需求的增加。代谢重编程，亦称为修改或失调的代谢，通过改变正常的代谢途径来产生生物量，以维持在营养匮乏的微环境中的癌细胞的生长、增殖和存活。已经描述了一系列涵盖不同代谢调控因子的失调/改变的代谢途径；然而，本综述重点阐述了诱导蛋白质/氨基酸代谢上调的代谢途径的深入理解。各种代谢循环的基本改变及其相应的结果同时探讨了在代谢调节中发挥关键作用的有希望的治疗靶点，成功地实现了针对特定靶点的有效癌症治疗。本综述旨在深入了解参与肿瘤进展的不同蛋白质/氨基酸的代谢重编程，同时展示了通过这些靶点进行的有希望的靶向癌症治疗的潜力。© 2023. 作者在 Springer-Verlag GmbH Austria 独家授权下，属于 Springer Nature 的一部分。

Cancer malignancies may broadly be described as heterogeneous disorders manifested by uncontrolled cellular growth/division and proliferation. Tumor cells utilize metabolic reprogramming to accomplish the upregulated nutritional requirements for sustaining their uncontrolled growth, proliferation, and survival. Metabolic reprogramming also called altered or dysregulated metabolism undergoes modification in normal metabolic pathways for anabolic precursor's generation that serves to continue biomass formation that sustains the growth, proliferation, and survival of carcinogenic cells under a nutrition-deprived microenvironment. A wide range of dysregulated/altered metabolic pathways encompassing different metabolic regulators have been described; however, the current review is focused to explain deeply the metabolic pathways modifications inducing upregulation of proteins/amino acids metabolism. The essential modification of various metabolic cycles with their consequent outcomes meanwhile explored promising therapeutic targets playing a pivotal role in metabolic regulation and is successfully employed for effective target-specific cancer treatment. The current review is aimed to understand the metabolic reprogramming of different proteins/amino acids involved in tumor progression along with potential therapeutic perspective elucidating targeted cancer therapy via these targets.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.