酪氨酸和セロトニン途径之间的失衡可能带来严重后果，例如抑郁症。导致酪氨酸代谢途径失衡的因素之一是炎症。我们的研究旨在评估肿瘤坏死因子-α（TNFα）抑制剂治疗对强直性脊柱炎（AS）患者色氨酸代谢的影响。我们招募了40例符合接受抗TNF-α治疗资格的AS患者（男性28例，女性12例，平均年龄40±11岁），并招募了一组对照组，包括20名健康志愿者（男性7例，女性13例，平均年龄38±5岁），来自普通人群。患者在治疗前后接受了全面的临床和生化评估。通过巴斯德强直性脊柱炎疾病活动指数（BASDAI）评估疾病活动性。采用Beck的抑郁指数（BDI）量表评估抑郁症的存在。测量了色氨酸、血清中的酪氨酸、色氨酸和喹啉酸的浓度。结果显示，AS患者（与对照组相比）的酪氨酸途径占优势（p<0.001）。令人惊讶的是，尽管临床病情有所改善，但AS患者在治疗后的血清色氨酸及其代谢产物水平未发现显著变化。此外，色氨酸代谢成分与AS的临床活动、抑郁症以及实验室炎症标志物的相关性不显著。可能还有其他因素影响着强直性脊柱炎患者的色氨酸代谢途径。© 2023. 作者（们）。

The imbalance between the kynurenine and serotonin pathways can have serious consequences, e.g., depression. One of the factors leading to the imbalance between the pathways of tryptophan metabolism is inflammation. The aim of our study was to assess the impact of treatment with tumor necrosis factor-alpha (TNFα)-inhibitors on tryptophan metabolism in patients with ankylosing spondylitis (AS). Forty patients with AS (twenty-eight males, twelve females; mean age 40 ± 11 years), qualified to receive anti-TNF-α treatment, were prospectively assessed. As a control group, 20 healthy volunteers (7 males and 13 females, mean age 38 ± 5 years) were recruited from the general population. Patients underwent full clinical and biochemical assessment before and after 6 months of therapy. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). The presence of depressive disorders was assessed with Beck's Depression Inventory (BDI) scale. Serum concentrations of tryptophan, serotonin, kynurenine, and quinolinic acid were measured. The predominance of the kynurenine pathway in AS patients (compared to the control group) was demonstrated (p < 0.001). Surprisingly, no significant changes in serum levels of tryptophan and its metabolites in AS patients after treatment were found, despite clinical improvement. Moreover, the components of tryptophan metabolism did not correlate significantly with the clinical activity of AS, depression nor laboratory inflammatory markers. Probably some other factors influence the pathways of tryptophan metabolism in patients with ankylosing spondylitis.© 2023. The Author(s).