细胞表面异常水平的糖脂是不同类型癌症的特征。仿真抗菌肽的酰化赖氨酸寡聚体（OAK）在体外对上调表达GD3和GM3神经胺酸脂的人类及小鼠黑色素瘤细胞系显示活性。本文通过X射线散射技术展示了OAK能够插入DPPC/GD3和DPPC/GM3脂质单层中的唾液寡糖脂。而在磷脂酰丝氨酸含量较高的脂质单层中缺乏插入现象，表明OAK对糖基化脂质膜的作用机制并不仅仅是由电荷效应驱动的。荧光显微镜数据显示了OAK的破膜活性。了解抗菌脂肽对GD3和GM3神经胺酸脂的选择性分子基础，将有助于开发治愈黑色素瘤及其他恶性肿瘤的新疗法。

Aberrant levels of glycolipids expressed on cellular surfaces are characteristic of different types of cancers. The oligomer of acylated lysine (OAK) mimicking antimicrobial peptides displays in vitro activity against human and murine melanoma cell lines with upregulated GD3 and GM3 gangliosides. Herein, we demonstrate the capability of OAK to intercalate into the sialo-oligosaccharides of DPPC/GD3 and DPPC/GM3 lipid monolayers using X-ray scattering. The lack of insertion into monolayers containing phosphatidylserine suggests that the mechanism of action by OAKs against glycosylated lipid membranes is not merely driven by charge effects. The fluorescence microscopy data demonstrates the membrane-lytic activity of OAK. Understanding the molecular basis for selectivity toward GD3 and GM3 gangliosides by antimicrobial lipopeptides will contribute to the development of novel therapies to cure melanoma and other malignancies.