聚合物胶束在药物传递系统（DDS）中得到广泛研究，它们的稳定性已被广泛认识，对药物传递有直接影响。本文合成了一系列亲水亲油共聚物LA-PDPAn-PVPm，制备了核交联纳米粒（CNP），以实现可控和靶向的抗癌药物传递。这些共聚物能够在水溶液中自组装，并形成尺寸在100至150纳米之间的均匀球形胶束。UCNP和CNP的比较表明，LA的交联能够显著提高纳米粒子的稳定性和响应能力。通过体外模拟药物释放实验，发现CNP在正常生理条件下具有良好的药物阻断能力，能够在酸性/还原条件下实现快速高效的药物释放。此外，细胞实验表明，CNP具有优异的生物相容性，能够靶向肿瘤细胞进行药物释放。总之，基于LA-PDPA-PVP共聚物的药物载体实现了有效的控制药物释放，结果为聚合物胶束用于药物载体的设计策略提供了指导。

Polymer micelles have been studied extensively in drug delivery systems (DDS), and their stability is well known to directly affect drug delivery. In this article, a series of amphiphilic copolymers LA-PDPAn-PVPm were synthesized to prepare core-cross-linked nanoparticles (CNP) applied to controllable and targeted anticancer drug delivery. The copolymers could self-assemble in aqueous solution and form homogeneous spherical micelles with particle sizes of between 100 and 150 nm. A comparison between un-cross-linked UCNP and CNP showed that the cross-linking of LA could significantly improve the stability and responsive ability of the nanoparticles. From the in vitro-simulated drug release experiments, CNP was found to have great drug blocking ability under normal physiological conditions and could achieve rapid and efficient drug release under acidic/reducing conditions. In addition, cell experiments showed that CNP had superior biocompatibility and could target tumor cells for drug release. In conclusion, a drug carrier based on copolymer LA-PDPA-PVP realized effective controlled drug release due to the cross-linking of LA. The results will provide guidance for the design strategy of polymer micelles for drug carriers.