气形炮膜家族成员气形炮膜 (gasdermin) 的发现作为促发炎性细胞死亡的执行者，为炎症相关细胞死亡的研究开辟了新的途径。虽然炎性细胞死亡的研究自三十年前被发现以来主要集中在免疫细胞上，但积累的证据表明炎性细胞死亡在许多生物过程中起着重要的作用。其中一个例子是发现了气形炮膜介导的癌细胞炎性细胞死亡 (CCP)，这已成为肿瘤学中一个重要而前沿的领域。最近的研究表明，CCP诱导可使肿瘤微环境变热，从而引发强大的抗肿瘤免疫，抑制肿瘤生长。作为一种新发现的肿瘤细胞死亡形式，CCP为改善肿瘤治疗和开发新的药物提供了有希望的机会。然而，对于CCP的研究仍处于初级阶段，并且对于气形炮膜的表达、调控和激活的分子机制还没有完全理解。在本综述中，我们总结了癌症领域中对气形炮膜的最新研究进展，并提出免疫细胞炎性细胞死亡 (ICP) 和 CCP 的抗肿瘤效应取决于它们的持续时间、强度和在肿瘤微环境中经历炎性细胞死亡的细胞类型。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

The identification of gasdermin as the executor of pyroptosis has opened new avenues for the study of this process. Although pyroptosis research has mainly focused on immune cells since it was discovered three decades ago, accumulating evidence suggests that pyroptosis plays crucial roles in many biological processes. One example is the discovery of gasdermin-mediated cancer cell pyroptosis (CCP) which has become an important and frontier field in oncology. Recent studies have shown that CCP induction can heat tumor microenvironment (TME) and thereby elicit the robust anti-tumor immunity to suppress tumor growth. As a newly discovered form of tumor cell death, CCP offers promising opportunities for improving tumor treatment and developing new drugs. Nevertheless, the research on CCP is still in its infancy, and the molecular mechanisms underlying the expression, regulation and activation of gasdermins are not yet fully understood. In this review, we summarize the recent progress of gasdermin research in cancer area, and propose that the anti-tumor effect of immune cell pyroptosis (ICP) and CCP depends on their duration, intensity, and the type of cells undergoing pyroptosis within TME.Copyright © 2023 Elsevier Ltd. All rights reserved.