慢性炎症虽然隐匿，但会使机体处于持续警觉状态，并与多种疾病，包括癌症和心血管疾病相关。它会促使造血细胞产生和释放促炎细胞因子，该细胞因子会激活造血干细胞(HSCs)中的特定信号通路，引起增殖、分化和迁移变化。当HSCs需要产生特定的血球以排除病原病毒等入侵物时，这种响应是必不可少的，但突变HSCs可以利用这些促炎信号来加速血液病或恶性肿瘤的发展。了解这一复杂过程对监测和控制患者疾病进展至关重要。在2023年冬季国际实验血液学学会（ISEH）网络研讨会中，Eric Pietras博士（美国科罗拉多州安舒茨医学校区）和Katherine Y. King博士（美国贝勒医学院）就这一主题进行了演讲，本综述文章对其进行了概述。版权所有 © 2023 Elsevier Inc.

Chronic inflammation, while subtle, puts the body in a constant state of alert and is associated with a number of diseases, including cancer and cardiovascular diseases. It leads hematopoietic cells to produce and release pro-inflammatory cytokines, which trigger specific signalling pathways in hematopoietic stem cells (HSCs) that cause changes in proliferation, differentiation, and migration. This response is essential when HSCs are needed to produce specific blood cells to eliminate an intruder, such as a pathogenic virus, but mutant HSCs can use these pro-inflammatory signals to their advantage and accelerate the development of haematological disease or malignancy. Understanding this complex process is vital in monitoring and controlling disease progression in patients. In the 2023 Winter International Society for Experimental Hematology (ISEH) webinar, Dr. Eric Pietras (University of Colorado Anschutz Medical Campus, USA) and Dr. Katherine Y. King (Baylor College of Medicine, USA) gave a presentation on this topic, which is summarized in this review article.Copyright © 2023. Published by Elsevier Inc.