癌症是全球死亡的主要原因。科学研究表明，自噬过程的打破常常与癌症的发生相关。因此，科学家正在寻求永久性解决方案来对抗这种致命疾病。吲哚生物碱已经被广泛研究，并被认为具有多种生物活性。当前的疾病状态需要新的药物分子的开发。在近几十年中，吲哚生物碱在癌症治疗中变得越来越重要，并且也被用作辅助剂。大量具有药理活性的分子来自广泛分布于自然界的吲哚生物碱。源自海洋生物的吲哚生物碱在治疗中展现出巨大的潜力，并且在癌症治疗中表现出很高的效果。已经进行了一些前临床实验来研究吲哚生物碱在癌症治疗中的可能性。源自海洋的吲哚生物碱通过多种抗增殖机制具有展示抗癌性质的能力。包括长春瑞旦和长春单胺在内的某些吲哚生物碱已经在临床试验中得到验证或正在进行临床评估，用于预防和治疗癌症。源自海洋资源的吲哚生物碱在发现新的抗肿瘤剂方面具有重要的功能。当前的文献强调了吲哚生物碱的最新进展，这些进展显示其具有抗癌药物的潜力以及其潜在机制。版权所有 © 2023 Elsevier B.V. 出版。

Cancer is the leading cause of mortality all over the world. Scientific investigation has demonstrated that disruptions in the process of autophagy are frequently interrelated with the emergence of cancer. Hence, scientists are seeking permanent solutions to counter the deadly disease. Indole alkaloids have been extensively studied and are acknowledged to exhibit several bioactivities. The current state of disease necessitates novel pharmacophores development. In recent decades, indole alkaloids have become increasingly significant in cancer treatment and are also used as adjuvants. A substantial amount of pharmacologically active molecules come from indole alkaloids, which are widely distributed in nature. Indole alkaloids derived from marine organisms show immense potential for therapeutic applications and seem highly effective in cancer treatment. A couple of experiments have been conducted preclinically to investigate the possibility of indole alkaloids in cancer treatment. Marine-derived indole alkaloids possess the ability to exhibit anticancer properties through diverse antiproliferative mechanisms. Certain indole alkaloids, including vincristine and vinblastine, were verified in clinical trials or are presently undergoing clinical assessments for preventing and treating cancer. Indole alkaloids from marine resources hold a significant functionality in identifying new antitumor agents. The current literature highlights recent advancements in indole alkaloids that appear to be anticancer agents and the underlying mechanisms.Copyright © 2023. Published by Elsevier B.V.