口腔黏膜疾病可能导致疼痛、言语和进食困难、心理困扰和癌症。使用生物大分子，尤其是水凝胶进行局部给药正因为传统口腔黏膜病变治疗的缺点而引起了兴趣。由天然高分子和其衍生物制成的生物水凝胶，例如壳聚糖、透明质酸、藻酸盐和明胶，是传统口腔药物给药方法的有希望的替代品。局部给药对于口腔黏膜病变有益，因为它可以直接靶向受影响的区域，尤其是随着智能刺激响应性水凝胶的开发，它可以实现更加可控的药物释放。生物水凝胶已被用于传递利多卡因和制霉菌素等药物。本综述总结了应用智能天然高分子水凝胶用于口腔黏膜病变药物转运的当前研究。智能生物水凝胶作为口腔黏膜病变的局部给药系统表现出极大的潜力，提供持续的药物释放、增强治疗效果和最小化全身性并发症。预计技术进步将带来更加有效和安全的药物输送系统的开发。生物高分子水凝胶的潜在益处使其成为口腔黏膜病变治疗研究的一个令人兴奋的领域。版权所有 © 2023。Elsevier B.V出版。

Oral mucosal diseases can lead to pain, difficulty speaking and eating, psychological distress, and cancer. Topical drug delivery using biological macromolecules, specifically hydrogels, is gaining interest due to the drawbacks of conventional treatments for oral mucosal lesions.Biological hydrogels made from natural polymers and their derivatives, such as chitosan, hyaluronic acid, alginate, and gelatin, represent promising alternatives to conventional oral medication delivery methods. Topical drug delivery is beneficial for oral mucosal lesions as it can directly target the affected area, especially with the development of smart stimuli-responsive hydrogels, which allow for more controlled drug release. Biological hydrogels have already been used to deliver drugs like lidocaine and nystatin. This review summarizes the current research on applying smart natural polymer-based hydrogels for drug delivery in oral mucosal lesions.Smart biological hydrogels show great promise as topical drug delivery systems for oral mucosal lesions, offering sustained drug release, increased therapeutic efficacy, and minimized systemic complications. Technological advancement is expected to lead to the development of more effective and safer drug delivery systems. The potential benefits of biological polymer-based hydrogels make them an exciting area of research for oral mucosal lesion treatment.Copyright © 2023. Published by Elsevier B.V.