18F-氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）已成为结直肠癌分期的必要手段，但仍存在局限性。因此，针对除葡萄糖外的代谢，主要是氨基酸代谢的PET技术得到了发展。L型氨基酸转运蛋白1（LAT1）被认为是一种癌细胞特异性氨基酸转运蛋白，虽然4-硼代-2-氟苯丙氨酸（FBPA）已被报道用作LAT1的探针，但LAT1在结直肠癌中的表达意义不明确，且尚未有关于18F-FBPA-PET在结直肠癌中的报告。本研究旨在通过免疫组化分析，调查LAT1在结直肠癌原发灶和转移灶中的表达情况，并报告在临床实践中对结直肠癌患者进行18F-FBPA-PET的初步经验。结果显示，原发肿瘤和肝转移灶的LAT1蛋白表达呈显著相关性。此外，LAT1的表达与复发呈正相关（p=0.033）。我们对3例直肠癌患者进行了18F-FBPA-PET，并成功检测到肿瘤。LAT1蛋白不仅在原发结直肠肿瘤中表达，而且在肝转移灶中也有表达。18F-FBPA-PET可以安全地应用于结直肠癌患者。版权所有 © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios)，保留所有权利。

18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG PET) has become indispensable for staging colorectal cancer but has limitations. Thus, PET with a focus on metabolism other than glucose, mainly amino acid metabolism, has been developed. L-type amino acid transporter 1 (LAT1) is known to be a cancer-specific amino acid transporter and, although 4-Borono-2-(18)F-fluoro-phenylalanine (FBPA) has been reported to be useful as a probe for LAT1, the significance of LAT1 expression in colorectal cancer is ambiguous and implementation of 18F-FBPA-PET in colorectal cancer has not yet been reported.The aims of this study were to investigate the expression of LAT1 in primary lesions and metastatic lesions of colorectal cancer by immunohistochemical analysis and report the initial experience of performing 18F-FBPA-PET on colorectal cancer patients in clinical practice.There was a significant correlation between LAT1 protein expression in primary tumors and liver metastases. Furthermore LAT-1 expression was positively correlated with recurrence (p=0.033). We performed 18F-FBPA-PET on three rectal cancer patients and detected cancer.LAT1 protein is expressed not only in the primary colorectal tumor, but also in liver metastases. 18F-FBPA-PET can be safely performed in patients with colorectal cancer.Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.