存在着长期暴露于弱射频（RF）场可能导致不良健康影响的重大关切。本研究中，HT-1080纤维肉瘤细胞同时暴露于静态磁通密度在10[Formula: see text]到300[Formula: see text]之间，并且幅度范围从1 nT到1.5 μT，频率范围从1.8到7.2 MHz的射频磁场中，并持续暴露四天。测量了细胞生长速率、细胞内pH值、过氧化氢、过氧硝酸根、细胞膜电位和线粒体钙离子浓度。结果与载波频率、射频磁场的幅度、调制频率和背景静态磁场（SMF）有关。铁硫（Fe-S）簇对于活性氧自由基和活性氮自由基（ROS和RNS）的产生至关重要。我们认为观察到的变化与化学活性电子和核自旋之间的超精细耦合有关。控制外部磁场可能对衰老、癌症、关节炎和阿尔茨海默病等具有重要的临床意义。© 2023。Springer Nature 有限公司。

There are substantial concerns that extended exposures to weak radiofrequency (RF) fields can lead to adverse health effects. In this study, HT-1080 fibrosarcoma cells were simultaneously exposed to a static magnetic flux density between 10 [Formula: see text] and 300 [Formula: see text] and RF magnetic fields with amplitudes ranging from 1 nT to 1.5 μT in the frequency range from 1.8 to 7.2 MHz for four days. Cell growth rates, intracellular pH, hydrogen peroxide, peroxynitrite, membrane potential and mitochondrial calcium were measured. Results were dependent on carrier frequency and the magnitude of the RF magnetic field, modulation frequencies and the background static magnetic field (SMF). Iron sulphur (Fe-S) clusters are essential for the generation of reactive oxygen species and reactive nitrogen species (ROS and RNS). We believe the observed changes are associated with hyperfine couplings between the chemically active electrons and nuclear spins. Controlling external magnetic fields may have important clinical implications on aging, cancer, arthritis, and Alzheimer's.© 2023. Springer Nature Limited.