恶性肿瘤患者在接受化疗过程中可能发生血栓栓塞事件（TEE），这是一个严重的不良事件，可导致严重的病症和死亡。有报道称，接受姑息化疗的胃癌（GC）患者TEE的发生率为5-27％。然而，很少有报告涉及GC辅助化疗（AC）时出现的TEE。本研究对在2013年1月至2020年6月期间，在一家单一中心接受了根治性切除手术后开始使用卡培他滨/奥沙利铂（167例）或S-1（444例）进行AC的611例GC患者（II期：309例，III期：302例）进行了回顾性分析。在AC过程中或AC完成后的1年内调查了TEE的发生率，并分析了影响TEE发生的因素。共有20名患者（3.3％）被确认出现TEE，其中几乎所有的患者都在S-1组（19例）中发生TEE。最常见的TEE类型是脑梗死和肺血栓栓塞（各有5例）。虽然高龄（≥ 70岁，p＜0.0001）、S-1治疗（p=0.021）和高血压（p=0.017）在单变量分析中被确定为TEE的显著危险因素，但只有高龄在多变量分析中与TEE的发生存在显著相关性（奥德斯比：3.07；95％置信区间1.11-8.48；p=0.031）。与之前的报告相比，在接受AC的GC患者中TEE的发生率较低。然而，正在接受AC治疗的年老的GC患者需要更加仔细地监测可能发生的TEE，考虑其相对较高的发生率。© 2023. 作者经独家许可授权给国际胃癌协会和日本胃癌协会。

Thromboembolic events (TEEs) are significant adverse events that can cause serious morbidities and mortality in cancer patients receiving chemotherapy. Patients with gastric cancer (GC) treated with palliative chemotherapy have been reported to experience a TEE incidence of 5-27%. However, very few reports have addressed TEEs in adjuvant chemotherapy (AC) for GC.This study retrospectively analyzed 611 GC patients (stage II: 309, III: 302) who started AC with capecitabine/oxaliplatin (167 patients) or S-1 (444 patients) after undergoing curative resection between January 2013 and June 2020 at a single center. The incidence of TEEs during AC or within 1 year after AC completion was investigated, while analyzing the factors that influenced the TEEs' occurrence.TEEs were confirmed in 20 patients (3.3%), and TEEs occurred in almost all patients in the S-1 group (19 patients). The most common TEE types were cerebral infarction and pulmonary thromboembolism (five patients each). Although old age (≥ 70 years, p < 0.0001), S-1 treatment (p = 0.021), and hypertension (p = 0.017) were identified as significant risk factors for TEEs in univariate analysis, only old age showed a statistically significant correlation with TEEs' occurrence in multivariate analysis (odds ratio: 3.07; 95% confidence interval 1.11-8.48; p = 0.031).TEEs occurred in fewer patients with GC who had been treated with AC than patients who had received palliative chemotherapy in previous reports. However, elderly GC patients who are undergoing AC require more careful surveillance for possible TEEs, considering relatively higher incidence of them.© 2023. The Author(s) under exclusive licence to The International Gastric Cancer Association and The Japanese Gastric Cancer Association.