唾液腺异位主要出现在人体头部和颈部区域，很少出现在直肠等区域，但在胰腺中尚未有相关研究证明存在。在对胰腺样本进行ΔNp63表达检测的筛查工作中，我们发现了来自35岁男性的两个胰腺样本显示出唾液腺异位。我们对健康和肿瘤性唾液腺的标记物进行了免疫组化染色，结果显示表达了卡尔波宁、CD142和KRT14，但没有S100p、GFAP或CD117的表达。PAS染色和Alcian Blue染色显示存在酸性粘液。这些染色模式与非肿瘤性颌下腺组织一致，包括丰富的腺泡、基底细胞和肌上皮细胞，而这些特征在胰腺中通常不存在。此外，未检测到胰岛细胞。我们首次展示了唾液腺异位可以出现在胰腺位置。© 2023年。生物医学中央出版社有限公司，斯普林格自然出版集团的一部分。

Heterotopia of the salivary gland occurs mainly in the head and neck region of the human body, rarely in regions such as the rectum, but has never been demonstrated in the pancreas. Within a screening effort of pancreatic samples for detecting ΔNp63 expression, we discovered two pancreatic samples from a 35-year-old male showing salivary gland heterotopia. Immunohistochemical stainings were done for markers of healthy and neoplastic salivary glands and showed expression of calponin, CD142 and KRT14 but not of S100p, GFAP or CD117. A PAS-staining and Alcian Blue staining showed the presence of acid mucins. These staining patterns were consistent with non-neoplastic submandibular gland tissue comprised of abundant seromucous glands, basal cells and myoepithelial cells, all features typically absent in the pancreas. Also, no pancreatic islets of Langerhans were detected. We show for the first time that salivary gland heterotopia can occur at the location of the pancreas.© 2023. BioMed Central Ltd., part of Springer Nature.