当前，全球女性仍然遭受着各种高发的女性常见疾病的困扰，诸如卵巢癌、子宫肌瘤和妊娠高血压（PE），其中一些疾病甚至具有高死亡率。作为G蛋白偶联受体（GPCR）信号通路中的负反馈调节因子，G蛋白信号调节蛋白（RGS）家族通过G鸟苷三磷酸（GTP）水解的转化作用，通过不稳定化酶底物复合物参与调控各种细胞生物学功能。最近的研究表明，G蛋白信号调节蛋白2（RGS2）作为RGS蛋白家族的成员，与某些女性疾病的发生和发展密切相关，为RGS2在维护女性健康方面的功能提供了证据。在本综述中，我们总结了RGS2在女性常见疾病中的当前认识，并探讨了通过靶向多种机制来发挥其治疗潜力。© 2023. BioMed Central Ltd., 由 Springer Nature 公司的一部分。

Currently, women around the world are still suffering from various female common diseases with the high incidence, such as ovarian cancer, uterine fibroids and preeclampsia (PE), and some diseases are even with the high mortality rate. As a negative feedback regulator in G Protein-Coupled Receptor signaling (GPCR), the Regulator of G-protein Signaling (RGS) protein family participates in regulating kinds of cell biological functions by destabilizing the enzyme-substrate complex through the transformation of hydrolysis of G Guanosine Triphosphate (GTP). Recent work has indicated that, the Regulator of G-protein Signaling 2 (RGS2), a member belonging to the RGS protein family, is closely associated with the occurrence and development of certain female diseases, providing with the evidence that RGS2 functions in sustaining women's health. In this review paper, we summarize the current knowledge of RGS2 in female common diseases, and also tap and discuss its therapeutic potential by targeting multiple mechanisms.© 2023. BioMed Central Ltd., part of Springer Nature.