印度阿萨姆邦的迪布鲁-斯艾克洪沼国家公园和生物圈保护区（DSNPBR）是生物多样性热点和许多兰花物种的贮藏室。本文通过系统回顾的方式，记录了DSNPBR中兰花的药用重要性，并分析了它们在药物发现中的重要性。本系统回顾采用了《系统回顾和荟萃分析的首选报告项目》（PRISMA）的指南进行。使用科学数据库搜索相关文献，记录DSNPBR中兰花物种的民族药用、药理活性和植物化学信息。我们分析了84篇文章，记录了DSNPBR中52个兰花物种的相关信息。铁线莲属（n=13）是最多的属。DSNPBR中的不同兰花物种在印度、尼泊尔、孟加拉国和中国等地传统上用于治疗胃肠疾病、与疾病相关的疼痛和炎症、皮肤病、伤口、关节炎、月经疼痛、结核等。临床前研究证实兰花的提取物/分馏物/分离化合物通过不同机制具有抗风湿、抗癌、抗肿瘤、抗炎、抗糖尿病、抗微生物、肾脏保护和神经保护活性。从铁线莲属物种如铁线莲生物碱、多糖中分离的生物分子表明其有望成为未来药物分子。许多分离出的植物化学物质在体外表现出抗癌活性。临床数据对于证明兰花的治疗有效性存在重大限制。DSNPBR中发现的兰花因其药用属性在传统文化中具有重要意义，并已成功研究其生物活性。然而，为了确认它们作为治疗剂的有效性，有必要进行有系统的研究，研究其分子机制，并进行毒性测试。版权所有©Bentham Science Publishers；有任何疑问，请发送电子邮件至epub@benthamscience.net。

Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part of biodiversity hotspots and a store house of many orchid species. This systematic review was conducted to document the medicinal importante of orchids available in DSNPBR and to analyse their importance in drug discovery.This systematic review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Scientific databases were used to search relevant literature to document ethnomedicinal uses, pharmacological activity and phytochemistry of orchid species available in DSNPBR.We have analysed 84 articles to document relevant information on 52 orchid species available in DSNPBR. Dendrobium (n=13) is the top genus. Different orchid species available in DSNPBR were used traditionally in India, Nepal, Bangladesh, and China to cure gastrointestinal disorders, disease-associated pain and inflammation, skin diseases, wound, arthritis, menstrual pain, tuberculosis etc. The pre-clinical investigations confirmed that extract/fraction/isolated compounds of orchids possess antirheumatic, anticancer, antitumor, anti-inflammatory, antidiabetic, antimicrobial, nephroprotective and neuroprotective activities through different mechanisms. Biomolecules isolated from orchid species like Dendrobium nobile alkaloids, polysaccharides have shown a potential to be developed as future drug molecules. Many phytochemicals isolated have demonstrated in vitro anticancer activities. The lack of clinical data in support of the therapeutic effectiveness of orchids is a major limitation.Orchids found in DSNPBR hold great significance in traditional culture for their medicinal properties and have been effectively studied for their bioactivities. Nevertheless, to confirm their effectiveness as therapeutics, conducting methodical research, examining their molecular mechanisms, and performing toxicity tests are necessary.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.