本研究旨在描述头颈部癌症相关疼痛的临床特征和不同疼痛表型的患病率。对100例头颈部癌症相关疼痛患者进行了横断面研究。所有患者进行了全面的临床评估，并根据国际头颈疼痛分类第一版和国际头痛分类第三版构建了一个或多个疼痛表型的分层。 在纳入的参与者中，68%为男性，队列的平均年龄为49.71±14.14岁。最常见的癌症部位是舌头（29%）和颊黏膜（24%）。通过11点数值语言疼痛评分标尺，平均疼痛强度为5.88±2.53，其中0表示 "没有疼痛"，10表示 "想象中最严重的疼痛"。然而，过去一个月内最严重的疼痛强度为8.95±1.53。每个患者的平均疼痛部位数为6个，最常见的疼痛描述词是隐痛、灼热和锐痛。肌筋膜疼痛、颌骨疼痛和烧灼疼痛是最常见的表型，平均共存三种不同表型。 头颈部癌症相关疼痛具有多样且复杂的临床特点，可能反映出原发性疼痛疾患（如肌筋膜疼痛、颌骨疼痛或烧灼疼痛疾患）的疼痛特征，并常以一簇表型的形式共同出现。 © 2023 Khawaja et al.

This study aimed to describe the clinical characteristics and prevalence of different painful phenotypes in head and neck cancer (HNC)-related pain.A cross-sectional study was conducted on 100 patients who presented with HNC-related pain. All patients underwent a comprehensive clinical assessment and were stratified in one or more painful phenotypes constructed based on the International Classification for Orofacial Pain, first edition, and International Classification for Headache Disorders, third edition.Among the participants included, 68% were male, and the mean age of the cohort was 49.71 ± 14.14 years. The most prevalent cancer sites were the tongue (29%) and buccal mucosa (24%). The average pain intensity was 5.88 ± 2.53 on an 11-point numeric verbal pain rating scale, where 0 was indicative of "no pain" and 10 was suggestive of "worst pain imaginable". However, the worst pain intensity over the last month was 8.95 ± 1.53. The average number of pain sites per patient was 6, and the most common pain descriptors were dull ache, burning, and sharpness. Myofascial pain, jaw bone pain, and burning pain disorder were the most common phenotypes, and on average, three different phenotypes co-existed.HNC-related pain has a varying and complex clinical profile, which may mirror the pain profiles of primary pain disorders, such as myofascial pain, jaw bone pain, or burning pain disorders, and often presents together as a cluster of phenotypes.© 2023 Khawaja et al.