伞形综述是对综述的综述，提供了三级证据。本篇综述综合了系统综述和荟萃分析，旨在确定口腔粘膜下纤维化（OSF）患者中口腔癌（OC）发展的比例。我们搜索了包括PubMed、Scopus、Web of Science、Cochrane和灰色文献在内的电子数据库。两位评审者独立筛选摘要并评估符合条件的论文。使用AMSTAR2评估了SR-MA的方法学质量，并检查了包含论文的证据质量。在初步搜索中确定了454篇论文，其中105篇进行了符合条件的筛选。符合纳入标准的有四篇SR-MA。OC比例在OSF病例中的范围为4.2%至6%。在所有四个MA中，这一结果呈现较大的异质性（I2 = 71.31%至86.37%）。没有一个综述评估了证据的质量，其中一半被判定具有严重低方法学质量。SR和MA中存在证据质量不足和严重的低方法学质量，导致较大的异质性。然而，由于潜在的恶性特性，应该仔细监测OSF患者以早期发现OC。© 2023 Wiley Periodicals LLC.

An umbrella review is a systematic review of systematic reviews, which provides a tertiary level of evidence. This umbrella review of systematic reviews and meta-analysis (SR-MA) aimed to determine the proportion of oral cancer (OC) development in oral submucous fibrosis (OSF) patients.We searched electronic databases including PubMed, Scopus, Web of Science, Cochrane and grey literature. Two reviewers independently screened abstracts and assessed for eligible papers. The methodological quality of SR-MA was evaluated using AMSTAR2, and we also checked the quality of evidence of the included papers.Out of 454 papers identified in the primary search, 105 underwent eligibility screening. Inclusion criteria were met by four SR-MA. OC ratios ranged between 4.2% and 6% for OSF. Substantial heterogeneity was observed for this outcome in all four MA (I2  = 71.31% to 86.37%). None of the SRs assessed the quality of evidence, and half of them were judged to be of critically low methodological quality.There is lack of quality of evidences and critically low methodological quality among SRs and MA leading to substantial heterogeneity. However, due to potentially malignant nature, OSF patients should be monitored carefully for early detection of OC.© 2023 Wiley Periodicals LLC.