川乌酸（PA）是从茯苓中提取出来的一种天然物质，具有抗炎和抗氧化的特性。然而，目前仍不清楚PA是否能够保护免受博来霉素（BLM）诱导的肺纤维化（PF）的影响。在本研究中，我们对给予BLM的小鼠中PA的效果进行了调查。我们的结果显示，PA显著改善了肺部损伤和病理表现。此外，PA降低了白细胞介素（IL）-6和肿瘤坏死因子（TNF）-α的水平，同时增加了IL-10的水平。PA还降低了肺组织中羟脯氨酸和丙二醛的水平，同时增加了超氧化物歧化酶和谷胱甘肽过氧化物酶的活性。此外，PA还抑制了BLM诱导的尿嘧啶基结构域含蛋白3（NLRP3）、ASC、IL-1β、P20和TXNIP的升高。总之，我们的研究证明了PA对BLM诱导的小鼠PF具有保护作用，通过抑制纤维化、炎症和氧化应激途径。© 2023年作者（们），在Springer Science+Business Media公司独家许可下，Springer Nature的一部分。

Pachymic acid (PA), a natural extract from Poria cocos (Schw.) Wolf, possesses anti-inflammatory and anti-oxidative properties. However, it is still unknown whether PA can protect against bleomycin (BLM)-induced pulmonary fibrosis (PF). In this study, we investigated the effects of PA in mice administered BLM. Our results showed that PA significantly improved lung damage and pathological manifestations. Additionally, PA reduced the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, while increasing the level of IL-10. PA also decreased the levels of hydroxyproline and malondialdehyde, and increased the activities of superoxide dismutase and glutathione peroxidase in lung tissue. Furthermore, PA inhibited the increases in pyrin domain-containing protein 3 (NLRP3), ASC, IL-1β, P20, and TXNIP induced by BLM. In conclusion, our study demonstrated the protective effects of PA against BLM-induced PF in mice by suppressing fibrotic, inflammatory, and oxidative stress pathways.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.