人类乳头瘤病毒（HPV）疫苗接种率仍然显著低于其他常见儿童疫苗的接种率，这对未来与HPV相关的口咽喉鳞状细胞癌（OPSCC）的发病率产生影响。为了评估知晓HPV与OPSCC之间关联的个体是否更有可能已经接种过疫苗，本调查研究纳入2020年9月1日至2021年5月19日期间在波士顿医学中心耳鼻喉科门诊就诊的18至45岁的患者。参与者接收到了一份由验证问卷（HPV相关头颈癌流行病学、认知和人口统计学）[HEAD]构成的调查问卷，以评估患者的HPV和HPV疫苗知识以及接种疫苗的障碍。该调查与一个新颖的耳鼻喉科部门的现场接种计划相关联。主要结果是基于调查反应的患者了解HPV感染与OPSCC之间关系的流行程度。通过多元逻辑回归分析，评估了患者对HPV相关OPSCC认知与接种疫苗可能性之间的关联，包括整体患者群和人口统计学特征。 共给予405名患者调查问卷，其中288人（71.1%）作出了回应。这些患者中，包括了271人（94.1%）的调查问卷；女性158人（58.3%），年龄中位数29岁（四分位数，24-35岁）。调查对象中的基线接种率低（26.6%；n = 72），全体中男性接种率为10.6%（113人中的12人），女性接种率为37.9%（158人中的60人）。很少有参与者理解HPV感染与OPSCC之间的关系（271人中的63人 [23.3%]），或了解HPV相关OPSCC是最常见的HPV相关癌症类型（121人中的9人 [7.4%]）。与男性相比，女性更有可能已经接种过疫苗（比值比 [OR]，6.5；95% CI，3.0-13.9），更了解HPV引起癌症（OR，3.7；95% CI，1.9-7.1），并更有可能从医疗保健从业者那里了解到HPV和HPV疫苗（OR，2.6；95% CI，1.2-5.7）。了解HPV感染与癌症以及HPV和OPSCC之间关系的知识与已接种疫苗的可能性增加相关（HPV和癌症：OR，4.1 [95% CI，1.8-9.5]；HPV和OPSCC：OR，3.7 [95% CI，1.8-7.6]）。在156名未接种疫苗的参与者中，98名男性中有12个人（12.2%），131名女性中有7个人（5.3%）接受了现场接种。 这项调查研究的大部分参与者并不知道HPV引起OPSCC。理解HPV引起OPSCC与已接种疫苗的可能性增加相关。然而，大多数受访患者并没有从他们的医疗保健从业者那里了解到这种关联。通过针对未接种成人的定向教育，建立HPV感染与OPSCC之间的关系，并结合现场接种，可能是提高成人HPV疫苗接种率的创新策略。

Human papillomavirus (HPV) vaccination rates remain significantly below rates for other common childhood vaccines, which has implications for future rates of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).To assess whether individuals who were aware of the association between HPV and OPSCC would be more likely to have been previously vaccinated.This survey study included patients aged 18 to 45 years who sought routine outpatient care at the otolaryngology clinic at Boston Medical Center from September 1, 2020, to May 19, 2021. A survey (HPV-Associated Head and Neck Cancer Epidemiology, Awareness and Demographics) [HEAD]) composed of validated questions to assess patient knowledge of HPV and HPV vaccination and barriers to vaccination was delivered to participants. The survey was paired with a novel point-of-care vaccination program housed within an otolaryngology department.The main outcome was prevalence of knowledge of the relationship between HPV infection and OPSCC based on survey responses. The association of knowledge of HPV-associated OPSCC with likelihood of having been vaccinated was assessed in the overall cohort and by demographic characteristics using multivariate logistic regression.Of 405 patients given the survey, 288 (71.1%) responded. Of these patients, 271 (94.1%) had surveys included; 158 (58.3%) were female, and median age was 29 years (IQR, 24-35 years). The baseline vaccination rate in the surveyed population was low (26.6%; n = 72) overall (10.6% among men [12 of 113]; 37.9% among women [60 of 158]). Few participants understood the relationship between HPV infection and OPSCC (63 of 271 [23.3%]) or that HPV-associated OPSCC is the most common HPV-associated cancer type (9 of 121 [7.4%]). Compared with men, women were more likely to have been previously vaccinated (odds ratio [OR], 6.5; 95% CI, 3.0-13.9), more aware that HPV causes cancer (OR, 3.7; 95% CI, 1.9-7.1), and more likely to have heard about HPV and HPV vaccination from their health care practitioner (OR, 2.6; 95% CI, 1.2-5.7). Knowledge of the relationship between HPV infection and cancer and between HPV and OPSCC was associated with increased likelihood of having been vaccinated (HPV and cancer: OR, 4.1 [95% CI, 1.8-9.5]; HPV and OPSCC: OR, 3.7 [95% CI, 1.8-7.6]). Among 156 unvaccinated participants, 12 of 98 men (12.2%) and 7 of 131 women (5.3%) received point-of-care vaccination.Most participants in this survey study were unaware that HPV causes OPSCC. Understanding that HPV causes OPSCC was associated with increased likelihood of having been vaccinated. However, most patients surveyed were not informed of this relationship by their health care practitioners. Targeted education aimed at unvaccinated adults establishing the relationship between HPV infection and OPSCC, paired with point-of-care vaccination, may be an innovative strategy for increasing HPV vaccination rates in adults.