2019年冠状病毒病（COVID-19）在男性中比女性更容易严重。其与性激素作为男性患者恶化因素的关联已引起关注。本研究旨在调查血清睾酮是否与COVID-19的恶化有关。测量和检验了2020年2月1日至2021年3月31日期间入院札幌医科大学医院的116名男性COVID-19患者和剩余血清的血清睾酮浓度。从这些COVID-19患者收集的血液样本进行分析。轻度、中度和重度组中，严重COVID-19在入院时的血清睾酮水平分别为2.19±1.35、1.29±0.88和0.75±0.58 ng/ml。入院时有严重COVID-19的患者睾酮水平较低（p<0.001）。在1.31 ng/ml的截断水平下，比较严重和非严重病例的曲线下面积为0.825。此外，血清睾酮水平与C-反应蛋白和血清淀粉酸水平呈负相关，与钙、锌、C3和C4呈正相关。在COVID-19男性患者中，低血清睾酮水平与疾病的严重程度相关，伴随强烈的炎症反应和补体消耗比例。版权所有 © 2023，国际抗癌研究所（George J. Delinasios博士），保留所有权利。

Coronavirus disease 2019 (COVID-19) is more likely to be severe in men than in women. Its association with sex hormones as an aggravating factor for male patients has been attracting attention. This study aimed to investigate whether serum testosterone is associated with the aggravation of COVID-19.Serum testosterone concentrations in 116 male patients with COVID-19 and residual serum were measured and examined upon their admission to Sapporo Medical University Hospital between February 1, 2020 and March 31, 2021.Blood samples collected from these patients with COVID-19 were analyzed. The serum testosterone levels were 2.19±1.35, 1.29±0.88, and 0.75±0.58 ng/ml in mild, moderate, and severe groups, respectively. Patients with severe COVID-19 on admission had lower testosterone levels (p<0.001). At a cutoff level of 1.31 ng/ml, the area under the curve for the comparison of severe with non-severe cases was 0.825. Furthermore, serum testosterone levels negatively correlated with C-reactive protein and serum amyloid A levels but positively correlated with calcium, zinc, C3, and C4.In male patients with COVID-19, low serum testosterone levels correlated with disease severity, accompanied by a strong inflammatory reaction and proportion of complement consumption.Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.